UPADACITINIB

Upadacitinib is a specific and transient inhibitor of intracellular Janus kinase (JAK) enzymes (preferentially JAK1 or JAK1/3), which are involved in the signaling pathway that stimulates immune cell activity and hematopoiesis. By blocking JAK, phosphorylation and activation of proteins called signal integrators and activators of transcription (STATs) that control how genes are expressed and how cells work are stopped.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Uses

Upadacitinib is used in the following conditions:

Upadacitinib

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Upadacitinib in people with the following conditions:

Current TB
Lactation
Severe illness that is active
Serious liver impairment
Pregnancy
Administering live vaccinations concurrently

Side Effects

Upadacitinib may have the following side effects:

Nausea
Upper respiratory tract infection
Increased blood creatine phosphokinase
Anemia
Neutropenia
Cough
Herpes zoster
Hepatitis B
Non-melanoma skin cancer
Lymphoma
Gastrointestinal perforation
AST/ALT
Lymphopenia
Increased lipid parameters
Pyrexia
Increased weight

Potentially Fatal:

Pulmonary or extrapulmonary TB
Oral/esophageal candidiasis
Pulmonary embolism
Pneumocytosis
Multidermatomal herpes zoster
Bacterial meningitis
Cryptococcosis
DVT
Cellulitis
Arterial thrombosis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness, or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Diverticular disease background
Taking NSAIDs
Cancer
High blood pressure
Hyperlipidemia
Infection that persists throughout time
Severe infection in the past
T.B. exposure
Traveled or lived in regions where TB or endemic mycoses are prevalent
Underlying issues that increase the risk of infection
Personal background
Overweight
Undergoing a big operation
Prolonged inactivity
Significant renal impairment

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients, which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Upadacitinib may interact with the following medicines:

Biologic DMARDs
Clarithromycin
Ciclosporin
Rifampicin
Azathioprine
JAK inhibitor
Tacrolimus
Phenytoin
Ketoconazole

Potentially Fatal:

Live vaccinations

Inform your physician about the drugs you take, including over-the-counter medications, prescribed drugs, supplements, and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

If an overdose is suspected, call your health care provider immediately.

Available Brands:

RINVOQ