Peptic ulcer disease refers to painful sores or ulcers in the lining of the stomach or first part of the small intestine, called the duodenum.
Causes of Ulcers
- No single cause has been found
- End result of an imbalance between digestive fluids in the stomach and duodenum
- Most ulcers are caused by Helicobacter pylori (H. pylori) bacterial infection
Factors that can increase your risk for ulcers include:
- Use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, naproxen (Aleve, Anaprox, Naprosyn, and others), ibuprofen (Motrin, Advil, some types of Midol, and others)
- Excess acid production from gastrinomas, tumors of the acid producing cells of the stomach that increases acid output (seen in Zollinger-Ellison syndrome)
- Excessive Alchohol intak
- Smoking or chewing tobacco
- Serious illness
- Radiation treatment to the area