Temoporfin is a porphyrin derivative that is used as a photosensitizing agent in photodynamic therapy. The antitumor activity of temoporfin is activated by the application of 652 nm light. It activates macrophages to produce more tumor necrosis factor-α (TNF-α) and nitric oxide (NO) which contributes to the efficacy of therapy through phagocytosis of cancer cells and increased cell death and oxidative damage through reactive nitrogen species.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Temoporfin is used in the following conditions:

  • Palliation of advanced head and neck squamous cell carcinoma


This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Temoporfin in people with the following conditions:

  • Porphyrias or other diseases exacerbated by light
  • Tumors known to be eroding into a major blood vessel in or adjacent to the illumination site
  • Planned surgical procedure within the next 30 days
  • Coexisting ophthalmic disease likely to require slit-lamp examination within the next 30 days
  • Existing photosensitising therapy
  • Pregnancy
  • Lactation

Temoporfin may have the following side effects:

  • Local hemorrhage
  • Facial pain
  • Facial edema
  • Burning sensation
  • Injection site reaction
  • Pain at injection site
  • Scarring
  • Mouth necrosis
  • Dysphagia
  • Nausea
  • Vomiting
  • Constipation
  • Anemia
  • Giddiness
  • Blisters
  • Trismus
  • Localised infection
  • Fever
  • Photosensitivity reaction
  • Skin necrosis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Avoid exposure to direct sunlight or bright indoor light for at least 15 days after administration or after which re-introduce to normal light gradually
  • Special care must be taken to prevent extravasation at the injection site; If extravasation occurs, protect the area from light for at least 3 months


Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Temoporfin may interact with the following medicines:

  • Topical fluorouracil


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If an overdose is suspected, call your health care provider immediately.

Available Brands:


  • Foscan

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