COMMON BRAND NAME(S): Ketek
GENERIC NAME(S): TELITHROMYCIN
Description: Telithromycin is a semisynthetic ketolide antibiotic that blocks protein of the bacteira. It may also inhibit the assembly of nascent ribosomal units.
Absorption: Rapidly absorbed from the GI tract. Bioavailability: 57%. Time to peak plasma concentration: Approx 1-3 hr.
Distribution: Widely distributed in body fluids and tissues, including the resp tract. Volume of distribution: 2.9 L/kg. Plasma protein binding: 60-70%.
Metabolism: Undergoes hepatic metabolism by CYP3A4 and non-CYP3A4 isoenzymes to 4 major metabolites.
Excretion: Via urine (13% as unchanged drug; remainder as metabolites) and faeces (7%). Elimination half-life: 2-3 hr. Terminal half-life: Approx 10 hr.