Talampicillin is a drug that belongs to the penicillin group of antibiotics. It is structurally related to the drug ampicillin and is used to treat infections as an antibiotic.

Talampicillin is used in the treatment of susceptible infections.

Talampicillin should not be given to people with a known hypersensitivity to ampicillin or other penicillins.

Talampicillin may have the following side effects, which are observed with ampicillin use:

  • Nausea
  • Vomiting
  • Diarrhoea
  • Erythematous maculo-papular rashes
  • Sore mouth
  • Black/hairy tongue
  • Rash
  • Erythema multiforme
  • Stevens-Johnson syndrome
  • Toxic epidermal necrolysis
  • Angioedema
  • Fever
  • Joint pains
  • Serum sickness-like symptoms
  • Haemolytic anaemia
  • Thrombocytopenia
  • Leucopenia
  • Neutropenia
  • Coagulation disorders
  • Prolonged bleeding time and prothrombin time
  • CNS toxicity (e.g. convulsions)
  • Paraesthesia
  • Nephropathy
  • Interstitial nephritis
  • Hepatitis
  • Cholestatic jaundice
  • Moderate and transient increase in transaminases


Extra caution should be observed with the following conditions:

  • Patient w/ history of β-lactam allergy
  • Kidney disease
  • Pregnancy
  • Breastfeeding



Talampicillin may interact with the following medicines:

  • Oral contraceptives
  • Warfarin
  • Phenindione
  • Oral typhoid vaccines
  • Methotrexate
  • Probenecid
  • Sulfinpyrazone
  • Allopurinol
  • Chloroquine
  • Bacteriostatic antibacterials (e.g. erythromycin, chloramphenicol, tetracycline)

If you think you may have used Talampicillin more than the usual dose, seek medical help immediately.


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