SULFINPYRAZONE - Watsons Health

SULFINPYRAZONE

Description: Sulfinpyrazone increases urinary excretion of uric acid by inhibiting tubular reabsorption of uric acid.

Pharmacokinetics:

Absorption: Rapidly and completely absorbed from the GI tract

Distribution: 98% bound to plasma proteins. Plasma half-life of about 2-4 hr.

Metabolism: Undergoes hepatic glucuronidation and oxidation.

Excretion: Unchanged drug and metabolites mainly excreted in urine

Indications:

This medication is used to prevent gout and gouty arthritis. It will not treat a sudden/severe attack of gout and may make it worse.

Contraindications:

Should not be given to patients with active peptic ulcer symptoms, blood dyscrasias, and known allergic reactions to this drug.

How to use sulfinpyrazone

Dosage: Take 200 to 400 mg this medication by mouth, usually twice daily or as directed by your doctor.

  • Take it with food, milk, or antacids to reduce stomach upset.
  • To prevent kidney stones, it is best to drink a full glass of water (8 ounces or 240 milliliters) with each dose and at least another 8 glasses a day while taking this drug. If your doctor has directed you to restrict your fluid intake, consult your doctor for further instructions
  • If you are also taking cholestyramine, take sulfinpyrazone at least 1 hour before or 4-6 hours after cholestyramine. Consult your doctor for more details.
  • Sulfinpyrazone should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication. You may experience an increase in the number of gout attacks for several months after starting this medicine while the body removes extra uric acid.
  • Sulfinpyrazone is not a pain reliever. To relieve pain from gout, continue to take your medicines prescribed for pain from gout attacks (e.g., colchicine, ibuprofen, indomethacin) as directed by your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Tell your doctor if your condition persists or worsens.

Not available.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Common side effects:

  • nausea,
  • heartburn,
  • dizziness, and
  • ringing in the ears may occur.

If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor immediately if any of these unlikely but serious side effects occur:

  • lower back pain,
  • swelling of the arms/legs/feet,
  • difficult/painful urination,
  • change in amount/color of urine

Tell your doctor immediately if any of these rare but very serious side effects occur:

  • easy bruising/bleeding,
  • bloody/black/tarry stools, fast/irregular heartbeat, signs of infection (e.g., fever, sore throat), severe stomach/abdominal pain, vomit that looks like coffee grounds, unusual tiredness.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions:

  • Allergy: Before taking sulfinpyrazone, tell your doctor or pharmacist if you are allergic to it; or to phenylbutazone or other pyrazoles; or if you have any other allergies.
  • Medical condition: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: bleeding/inflammation in the stomach or intestines (e.g., active peptic ulcer disease), severe kidney disease, a certain type of kidney stone (urate/uric acid).
  • Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems (e.g., low platelets, blood clotting problems), low blood counts (e.g., anemia, low white blood cells), cancer of the blood (e.g., leukemia), radiation treatment for cancer, diabetes, kidney disease, history of peptic ulcer disease.

Pregnancy Risk: During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Breasfeeding: It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions:

  • This drug should not be used with the following medications because a very serious interaction may occur: cancer chemotherapy, “clot-busting” drugs/thrombolytics (e.g., streptokinase).
  • Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: “blood thinners” (e.g., warfarin, dipyridamole), nitrofurantoin, NSAIDs (e.g., ibuprofen, indomethacin, naproxen), salicylates (e.g., high-dose aspirin), certain anti-seizure medication (hydantoins such as phenytoin).
  • Alcohol can decrease this drug’s effectiveness. Limit alcohol while taking this medication.
  • Aspirin can prevent this medication from being fully effective. Avoid aspirin and other salicylates while taking this medication. Many nonprescription products contain aspirin.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose:

If overdose is suspected, contact a poison control center or emergency room immediately.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (e.g., uric acid blood levels, kidney function tests, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Your doctor may recommend a low-purine diet to help treat your gout. Follow your doctor’s instructions carefully.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Brands:

Also marketed as

  • Sulfin [ American Taiwan Biopharma ]

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