Description: Solifenacin is a muscarinic receptors antagoinst resulting in decreased urinary bladder problems.


Absorption: Highest concentration in the blood 3 to 8 hours after oral administration.

Distribution: Protein binding: 98%.

Metabolism: Metabolised largely in the liver, mainly by CYP3A4.

Excretion: Excreted mainly as metabolites in the urine and faeces.


Solifenacin is used to treat an overactive bladder with symptoms of frequent urination, frequent feeling of need to urinate, and inability to hold urine in the bladder.


Should not be given to patients with: urinary retention, gastric retention, glaucoma, and those who had allergic reactions with the drug.

How to use solifenacin

Dosage: Take 5 mg of this medication by mouth with or without food as directed by your doctor, usually once a day.

  • Take it with a full glass of liquid. Swallow this medication whole because the powder in the tablet has a strong bitter taste.
  • Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition does not improve or if it worsens.

Availability: This is a prescription only drug.

Not available.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Common side effects:

  • dry mouth (suck sugarless hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute)
  • constipation (eat a diet adequate in fiber, drink plenty of water, and exercise),
  • drowsiness,
  • stomach upset,
  • blurred vision,
  • dry eyes,
  • headache, or
  • unusual tiredness/weakness

Tell your doctor right away if you have any serious side effects, including:

  • severe stomach/abdominal pain,
  • constipation for 3 or more days,
  • difficulty urinating,
  • signs of kidney infection (such as burning/painful/frequent urination, fever, pink/bloody urine),
  • mental/mood changes (such as confusion, hallucinations)

Get medical help right away if you have any very serious side effects, including:

  • eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.



This drug may make you drowsy or cause blurred vision.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.

  • Allergy: Before taking solifenacin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
  • Medical History: Before using this medication, tell your doctor or pharmacist if you had: difficulty urinating (urinary retention), other bladder problems (such as bladder outflow obstruction), stomach/intestinal blockage (gastric retention), personal or family history of glaucoma (angle-closure type), liver disease, bowel disease (such as ulcerative colitis), slowed movement of stomach/intestines, constipation, kidney disease, enlarged prostate, a certain muscle/nerve disease (myasthenia gravis).
  • Anaphylactic reactions: Angioedema of the face, lips, tongue, and/or larynx have been reported with solifenacin. In some cases angioedema occurred after the first dose.
  • Urinary retention
  • Gastrointestinal disorders
  • Central nervous system effects: A variety of CNS anticholinergic effects have been reported, including headache, confusion, hallucinations and somnolence. If a patient experiences anticholinergic CNS effects, dose reduction or drug discontinuation should be considered.

Pregnancy Risk: Category C- During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Breastfeeding: It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.


  • Some products that may interact with this drug include: pramlintide, potassium tablets/capsules.
  • Other medications can affect the removal of solifenacin from your body, which may affect how solifenacin works. Examples include certain azole antifungals (such as itraconazole, ketoconazole), among others.


If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include fast/irregular heartbeat, agitation.


Do not share this medication with others.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.


Available Brands

  • Vesicare [ Astellas ]

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