Precautions
General:
Before having surgery, tell your doctor or dentist that you are using this medication.
This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.
This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.
Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially stomach bleeding and kidney problems.
- Allergy: Before taking salsalate, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (e.g., ibuprofen, naproxen, celecoxib); or to salicylic acid
- Medical Conditions: This medication should not be used if you have:
- aspirin-sensitive asthma (a history of worsening breathing with runny/stuffy nose after taking aspirin or other NSAIDs),
- severe kidney disease.
- Medical History: Before using this medication, tell your doctor or pharmacist your medical history, especially of:
- liver disease,
- poorly controlled diabetes,
- stomach/intestine/esophagus problems (e.g., bleeding, ulcers, recurring heartburn), heart disease (e.g., history of heart attack),
- high blood pressure,
- stroke,
- swelling of the ankles/feet/hands,
- blood disorders (e.g., anemia),
- bleeding/clotting problems,
- asthma,
- growths in the nose (nasal polyps),
- certain genetic conditions (G-6-PD deficiency, pyruvate kinase deficiency)
Pregnancy Risk: Category C- Drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breastfeeding: This drug may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug long-term and in high doses. Consult your doctor before breast-feeding.
Interactions
Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.
- Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), certain drugs for seizures (phenytoin, valproic acid), cidofovir, corticosteroids (e.g., prednisone), cyclosporine, drugs for gout (e.g., probenecid, sulfinpyrazone), drugs that affect the acidity of urine (e.g., ammonium chloride, acetazolamide), lithium, methotrexate, pemetrexed, tenofovir.
- This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin, among others.
- May enhance glucose lowering effect of anti-diabetic drug, such as sulfonylureas.
- Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, ketorolac, or naproxen) that are similar to this drug and, if taken together, may increase your risk for side effects. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Consult your doctor or pharmacist for more details.
- This medication may interfere with certain laboratory tests (including certain urine glucose tests, thyroid hormone levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
