Generic Name: ranolazine (ra-NOE-la-zeen)

Brand Name: Ranexa


Description: Ranolazine is an anti-anginal and anti-ischemic drug.  Its action is directed to Sodium and Calcium channels and transporters.

It is used to treat chronic chest pain (angina).

Ranozaline is in Pregnancy Category C.  No data to show the effects on pregnancy and breastfeeding has been reported.

More Common

  • Dizziness
  • Constipation
  • Nausea
  • Dizziness

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • Continuous ringing or buzzing or other unexplained noise in the ears
  • Difficult or labored breathing
  • Fast, irregular, pounding, or racing heartbeat or pulse
  • Feeling of constant movement of self or surroundings
  • Hearing loss
  • Lightheadedness
  • Rapid weight gain
  • Sensation of spinning
  • Tightness in the chest
  • Tingling of the hands or feet
  • Unusual weight gain or loss


  • Abnormal or decreased touch sensation
  • Agitation
  • Blood in the urine
  • Blurred vision
  • Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  • Chest pain or discomfort
  • Chills
  • Cold sweats
  • Coma
  • Confusion
  • Decreased urine output
  • Depression
  • Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • Fainting
  • Headache
  • Hostility
  • Irritability
  • Lethargy
  • Muscle twitching
  • Nausea
  • Seizures
  • Shakiness in the legs, arms, hands, or feet
  • Slow or irregular heartbeat
  • Stupor
  • Sweating
  • Trembling or shaking of the hands or feet
  • Unusual tiredness or weakness


Applies to the following strength(s): 500 mg ; 1000 mg

This information is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for Angina Pectoris

Initial dose: 500 mg orally twice daily

Maintenance dose: 500 mg to 1000 mg orally twice daily. Maximum recommended dose is 1000 mg twice daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Use of ranolazine is contraindicated in patients with clinically significant hepatic dysfunction.

Dose Adjustments

If satisfactory reduction of clinical symptoms has not been achieved, the dose may be increased to 1000 mg orally twice daily.


Data not available



Available Brands

  • Ranexa [ A. Menarini ]

Also marketed as

  • Razine [ Ajanta Pharma Phil ]

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