PENCICLOVIR TOPICAL

COMMON BRAND NAME(S): Denavir

GENERIC NAME(S): PENCICLOVIR

 

Description: Penciclovir inhitbits the Herpesviridae virus, including herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), and EpsteinBarr virus (EBV). This drug inhibits the Herpes virus by deoxyguanosine triphosphate; consequently, herpes viral DNA synthesis, then replication are selectively inhibited.

Pharmacokinetics:

Absorption: Not absorbed appreciably into systemic circulation following topical administration at single or multiple doses up to a total of 180 mg (approx 67 times the proposed daily clinical dose).

This medication is used to treat “cold sores/fever blisters” (herpes labialis). It can speed up healing of the sores and decrease symptoms (such as tingling, pain, burning, itching). Penciclovir belongs to a class of medications known as antivirals. It works by stopping the growth of the virus. This medication does not cure herpes, and it does not prevent passing the infection to someone else. It does not prevent future occurrences.

 

How to use penciclovir topical:

 

Use this medication at the first sign of infection (such as tingling, burning, redness, or sores). Wash your hands with soap and water before and after applying this medication. Clean and dry the affected areas before applying the medication. Apply a thin layer of penciclovir cream to completely cover the area of the cold sore or the area of tingling/itching/redness/swelling, and rub in gently. Apply the cream every 2 hours (except during sleep) for 4 days or as directed by your doctor.

 

Apply to skin only. Do not apply this medication in or near the eyes since this medication can irritate the eyes. If you do get medication in your eyes, flush with plenty of water. Do not apply inside the mouth or nose.

 

Dosage is based on your medical condition and response to treatment. Do not use this drug more often or for longer than prescribed.

 

Use this medication regularly to get the most benefit from it. This medication works best when the amount of drug absorbed by the skin stays at a constant level. Therefore, use this drug at evenly spaced intervals. To help you remember, use it at the same times each day.

 

Cold sores (herpes) can spread easily. Penciclovir cream does not prevent the spread of herpes. Avoid close physical contact with others (such as kissing) during an outbreak until the cold sores have completely healed. Also, try not to touch the cold sore, and wash your hands if you do touch the cold sore.

 

Tell your doctor if your condition persists or worsens after treatment is finished.

Pregnancy Risk: Category B (No proven risk in humans)

Redness, headache, burning, stinging, or numbness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

 

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

 

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions:

 

Before using penciclovir, tell your doctor or pharmacist if you are allergic to it; or to famciclovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

 

Before using this medication, tell your doctor or pharmacist your medical history.

 

Tell your doctor if you are pregnant before using this medication. Discuss the risks and benefits with your doctor.

 

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

 

Interactions:

 

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

 

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

 

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose:

 

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately.

 

Notes

Do not share this medication with others. Doing so may spread the infection.

 

Cold sore outbreaks can be triggered by many factors such as stress, hormonal changes (such as pregnancy, menstrual period), injury/surgery on the mouth (such as dental work), tiredness, sunlight, cold weather, or fever/cold/flu.

 

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

 

Storage

Store this medication at room temperature between 68-77 degrees F (20-25 degrees C). Firmly screw the cap back on the tube of medication after each use. Keep all medicines away from children and pets.

 

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Brands:

 

Available Brands:

Denavir

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