PAZOPANIB - Uses, Warnings, Side Effects, Precautions, Overdose,
Diquafosol

PAZOPANIB

Pazopanib is a synthetic second-generation tyrosine kinase (RTKs) inhibitor, which is involved in the initiation of signal transduction pathways that facilitates the proliferation of malignant cells and affects processes critical to cell survival and tumor progression.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Pazopanib is used in the following conditions:

  • Advanced renal cell carcinoma
  • Advanced soft tissue sarcoma

Do not use Pazopanib in people with the following conditions:

  • Pregnancy

Lactation

Pazopanib may have the following side effects:

  • Hypertension
  • Congestive heart failure
  • Decreased Left ventricular ejection fraction
  • QT prolongation
  • Torsade de pointes
  • Venous thrombosis
  • Thrombotic microangiopathy
  • Retinal tear/detachment
  • Hand-foot skin reaction
  • Hypothyroidism
  • Proteinuria
  • Pneumothorax
  • Thrombocytopenia
  • Neutropenia
  • Leukopenia
  • Polycythemia
  • Bradycardia
  • Chest pain
  • Blurred vision
  • Retinal detachment or tear
  • Diarrhea
  • Anorexia
  • Dysgeusia
  • Nausea
  • Vomiting
  • Abdominal pain
  • Stomatitis
  • Dyspepsia
  • Flatulence
  • Fatigue
  • Mucosal inflammation
  • Asthenia
  • Hyperhidrosis
  • Lethargy
  • Chills
  • Pancreatitis
  • Increased liver function test, creatinine, lipase, thyroid-stimulating hormone and blood glucose
  • Decreased weight
  • Decreased appetite
  • Edema
  • Arthralgia
  • Myalgia
  • Muscle spasms
  • Musculoskeletal pain
  • Neoplasms benign
  • Tumor pain
  • Headache
  • Dizziness
  • Paresthesia
  • Peripheral sensory neuropathy
  • Insomnia
  • Dysphonia
  • Cough
  • Dyspnea
  • Hiccups
  • Hair color change
  • Palmar-plantar erythrodysesthesia syndrome
  • Alopecia
  • Exfoliative rash
  • Hypopigmentation
  • Dry skin
  • Pruritus
  • Erythema
  • Depigmentation
  • Nail disorder

 

Potentially fatal:

  • Interstitial lung disease/pneumonitis
  • Myocardial ischemia
  • Ischemic stroke
  • Transient ischemic attacks
  • Epistaxis
  • Hemoptysis
  • Rectal or anal hemorrhage
  • Mouth hemorrhage
  • Pulmonary embolism
  • Serious infections (with or without neutropenia)
  • Headache
  • Seizure
  • Lethargy

 

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with history of QT interval prolongation
  • Pre-existing cardiac disease
  • Risk factors or history of thrombotic events
  • Risk of hemorrhage
  • Gastrointestinal perforation or fistula
  • Renal and mild to moderate hepatic impairment
  • Elderly

 

Prior in taking this medicine, tell your physician or pharmacist if you have allergies  or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

 

Interactions

Pazopanib may interact with the following medicines:

  • Midazolam
  • Dextromethorphan (metabolites
  • Paclitaxel
  • Irinotecan
  • Simvastatin
  • Haloperidol
  • Lapatinib

 

Potentially fatal:

  • Pemetrexed
  • Lapatinib
  • Itraconazole
  • Clarithromycin
  • Atazanavir
  • Nefazodon
  • Rifampin
  • Esomeprazole

 

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you think you have used Pazopanib more than the usual dosage, please seek medical help immediately.

Symptoms of overdose may include the following:

  • Grade 3 fatigue
  • Hypertension

 

Available Brands:

  • Votrient

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