OXAZEPAM

COMMON BRAND NAME(S): Serax

GENERIC NAME(S): OXAZEPAM

 

Description: Oxazepam is a short-acting benzodiazepine which enhancing the GABA inhibitory effects a calming and anti-seizure effect.

Pharmacokinetics:

Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: Approx 2-3 hr.

Distribution: It crosses the placenta and detected in breast milk. Plasma protein binding: Approx 97%.

Metabolism: Undergoes hepatic conjugation to produce the major inactive glucuronide metabolite.

Excretion: Via urine as inactive glucuronide conjugate. Elimination half-life: Approx 4-15 hr.

  • Used to
    • Treat anxiety
    • acute alcohol withdrawal
    • It is a benzodiazepine
  • May also be used to reduce the effects of insomnia

How to use oxazepam

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor
  • Minor side effects (if these symptoms persist or worsen, inform your doctor)
    • Drowsiness, dizziness, blurred vision, or headache
  • Serious side effects (inform your doctor immediately)
    • mental/mood changes, slurred speech, clumsiness, trouble walking, decreased/increased interest in sex, tremor, trouble urinating, sleep disturbances, fainting, stomach/abdominal pain, persistent nausea, vomiting, fatigue, yellowing eyes or skin, dark urine, persistent sore throat or fever.

Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, stomach/abdominal pain, persistent nausea, vomiting, fatigue, yellowing eyes or skin, dark urine, persistent sore throat or fever.

  • Severe allergic reactions are rare. Get immediate medical help if you notice the following:
    • Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

Precautions:

  • Inform your doctor if you
    • Are allergic to the medication
    • Have a history of liver disease, kidney disease, lung/breathing problems (e.g., COPD, sleep apnea), drug or alcohol abuse
  • May cause dizziness or drowsiness
    • Especially for older adults causing an increase in risk of falls
  • Not recommended for use during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.
  • Consult your doctor before breast-feeding as this medication passes into breast milk and may cause unwanted effects on your baby

 

Interactions:

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • Products that may interact with this medication include:
    • Do not use with Sodium oxybate
    • Clozapine, digoxin, kava
    • Drugs that cause drowsiness such as: antihistamines that cause drowsiness (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers.
  • Double check the labels on all medications you are currently taking especially cough-and-cold products since they may contain drowsiness-causing components
  • Smoking can decrease the effectiveness of this medication

Overdose:

If overdose is suspected, contact a poison control center or emergency room immediately.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

Storage

  • Room temperature between 59 and 86 degrees F (15-30 degrees C)
  • Do not expose to light and moisture
  • Do not store in the bathroom
  • Keep all medications away from pets and children

 

Brands:

Available Brands:

Serax

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