OXAPROZIN

COMMON BRAND NAME(S): Daypro

GENERIC NAME(S): OXAPROZIN

 

Description: Oxaprozin is a propionic acid derivative NSAID that blocks prostaglandin production to decrease pain and swelling

Pharmacokinetics:

Absorption: Slowly but almost completely absorbed from the GI tract. Peak plasma levels within 2-4 hr.

Distribution: Protein-binding: >99%.

Metabolism: Hepatic via oxidation and glucuronidation.

Excretion: Via urine (5% unchanged, 65% as metabolites); via faeces (35% as metabolites). Elimination half-life: 40-50 hr.

  • Used to
    • Treat arthritis as it reduces pain, swelling, and stiffness of the joints
    • It is a nonsteroidal anti-inflammatory drug (NSAID)
  • May also be used to treat gout

How to use oxaprozin

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor.
  • Taken by mouth; With a full glass of water (8 oz or 240 ml, may also be taken with food, milk or antacid to avoid stomach upset; usually once a day
  • Nonsteroidal anti-inflammatory drugs (including oxaprozin) may rarely increase the risk of a heart attack or stroke
  • Should not be taken right before or after heart bypass surgery (CABG)
  • May infrequently cause serious (rarely fatal) bleeding from the stomach or intestines
  • Minor side effects (if these symptoms persist or worsen, inform your doctor)
    • Upset stomach, constipation, diarrhea, nausea, vomiting, gas, heartburn, drowsiness, dizziness, or headache
    • May raise your blood pressure. Regular blood pressure monitoring is advised
  • Serious side effects (inform your doctor immediately)
    • Bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.
    • May rarely cause serious (possibly fatal) liver disease
      • Dark urine, persistent nausea/vomiting/loss of appetite, severe stomach/abdominal pain, yellowing eyes/skin.
  • Severe allergic reactions are rare. Get immediate medical help if you notice the following:
    • Rash, hives, itching/swelling (especially of the face/tongue/throat), dizziness, chest tightness, cough, trouble breathing.

Precautions:

  • Inform your doctor if you
    • Are allergic to the medication or to aspirin or other NSAIDs like as ibuprofen, naproxen, celecoxib
    • Have a history of asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), liver disease, stomach/intestine/esophagus problems (such as bleeding, ulcers, recurring heartburn), heart disease (such as history of heart attack), high blood pressure, stroke, blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps)
  • Kidney problems can sometimes occur
  • May cause dizziness or drowsiness
  • May cause stomach bleeding
    • Limit alcohol and stop smoking
  • May cause light sensitivity (photosensitivity)
    • Avoid prolonged sun exposure, tanning booths or sunlamps
    • Sunscreen and protective clothing are recommended when outdoors.
  • If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.
    • Not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery
  • It is not known if this drug passes into breast milk. Before breast-feeding, consult your physician.

 

Interactions:

Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

  • Products that may interact with this medication Include:
    • aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, lithium, methotrexate, “water pills” (diuretics such as furosemide)
    • anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin
  • Double check all the labels of the medications you are currently taking as many drugs contain pain relievers/fever reducers such as aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac that may increase your risk of side effects
  • If your doctor prescribed you low dose aspirin, continue to take it unless you are told otherwise

Overdose:

If overdose is suspected, contact a poison control center or emergency room immediately.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

Storage

  • Room temperature
  • Do not expose to light and moisture
  • Do not store in the bathroom
  • Keep all medications away from pets and children

 

Brands:

Available Brands:

Daypro

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