OPRELVEKIN SUBCUTANEOUS

COMMON BRAND NAME(S): Neumega

GENERIC NAME(S): OPRELVEKIN

 

Description: Oprelvekin is a recombinant human interleukin-11 platelet factor that promotes the production of platelets.

Pharmacokinetics:

Absorption: Bioavailability: About 80% (SC). Peak serum concentrations after about 3 hr.

Excretion: Via urine (mainly as metabolites). Clearance reduced in renal impairment. Terminal half-life: 7 hr.

  • Prevent very low platelet counts (thrombocytopenia)
  • Reduce the need for platelet transfusions

 

How to use oprelvekin subcutaneous

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor

Injected under the skin of the abdomen, thigh, hip, or upper arm; usually once daily; 6 to 24 hours after chemotherapy treatment or as prescribed by your doctor.

    • A very serious allergic reaction can occur with this medication

    If you develop an allergic reaction to this medication do not take it again. Consult your doctor physician for more details

      • Minor side effects (if these symptoms persist or worsen, inform your doctor)
        • Pain at the injection site
        • red eyes
        • dizziness

       

      • Serious side effects (inform your doctor immediately)
        • Fever, flushing, headache, severe weakness, sudden/unexplained weight gain, vswelling of the hands/ankles/feet, shortness of breath, muscle/bone pain, fast/pounding/irregular heartbeat, white patches in the mouth, unusual tiredness, change in the amount of urine, vision changes (e.g., blurred vision, loss of vision), fainting, confusion, weakness on one side of the body, slurred speech, chest pain.

       

      • Severe allergic reactions are rare. Get immediate medical help if you notice the following:

      Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

      • Precautions:
        • Inform your doctor if you
          • Are allergic to the medication or other quinolones such as levofloxacin or ciprofloxacin
          • Have a history of kidney disease, heart/blood vessel disease (e.g., congestive heart failure, irregular heartbeat, stroke), unusual fluid retention (e.g., swelling of the ankles/feet, ascites, pleural effusion), eye problems (e.g., papilledema), brain/spinal cord tumors, high blood pressure (hypertension).

         

        • Children may be at greater risk for eye/heart problems and bone changes while using this medication

         

        • During pregnancy, discuss the risks and benefits of use with your doctor.

         

        • It is unknown if this drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

         

        Interactions:

        Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

         

         

        Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

         

        • Products that may interact with this medication Include:
          • drugs that can decrease your potassium levels (e.g., “water pills”/diuretics such as furosemide/hydrochlorothiazide)
          • drugs that can cause fluid retention (e.g., corticosteroids such as prednisone)

         

        • Labratory tests that may be affected:

        calcium/albumin levels

      • Overdose: If overdose is suspected, contact a poison control center or emergency room immediately.

         

        Missed Dose

        If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.

         

        Storage

        • Keep in a refrigerator between 36-46 degrees F (2-8 degrees C)
        • Do not expose to light
        • Do not freeze
        • Mixed medication should be used within 3 hours and can be stored in the vial, at a refigerator temperature of 36-46 degrees F (2-8 degrees C) or at room temperature up to 77 degrees F (25 degrees)
        • Do not store in a syringe
        • Do not store in the bathroom
        • Keep all medications away from pets and children

         

        Brands:

         

        Available Brands:

        Neumega

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