Opipramol is a drug belonging to a class of medicines known as tricyclic antidepressants. It acts by blocking the re-uptake of noradrenaline and serotonin in the nerves.

Opipramol is used to treat depression.

Opipramol should not be used in the following conditions:

  • Intoxication with alcohol, barbiturates or benzodiazepines
  • Benign prostatic hypertrophy
  • Urinary retention
  • Glaucoma
  • Pyloric stenosis
  • Bowel obstruction
  • Predisposition to seizures or epilepsy
  • Severe liver problems
  • Severe kidney problems

Opipramol can lead to the following side effects:

  • Dry mouth
  • Stuffy nose
  • Fatigue
  • Drowsiness
  • Dizziness
  • Increased sweating
  • Blurred vision
  • Speech impairment
  • Tremors
  • Heart rhythm disturbances
  • Palpitations
  • Orthostatic hypotension
  • Liver dysfunction
  • Constipation
  • Weight gain
  • Urinary retention
  • Decreased libido
  • Increased thirst
  • Rash
  • Urticaria


Take caution if you have the following problems:

  • Bradycardia
  • Heart problems
  • Low blood potassium
  • Pregnancy
  • Lactation

Avoid sudden withdrawal of this drug.



Opipramol may interact with the following medicines:

  • Guanethidine
  • Clonidine
  • CNS depressants e.g. alcohol, sedatives or hypnotics
  • Cimetidine
  • Phenothiazines
  • Haloperidol
  • SSRIs
  • Oral anticoagulants
  • Quinidine
  • Other anticholinergics
  • Monoamine oxidase inhibitors (MAOIs)
  • Sympathomimetics

Symptoms of overdose include the following:

  • Excitement
  • Restlessness
  • Marked antimuscarinic effects (e.g. dry mouth, hot dry skin, dilated pupils, tachycardia, urinary retention, intestinal stasis)
  • Unconsciousness
  • Convulsions
  • Myoclonus
  • Hyperreflexia
  • Hypothermia
  • Hypotension
  • Metabolic acidosis
  • Respiratory and cardiac depression
  • Cardiac arrhythmias

Seek medical help immediately.


Available Brand:

  • Insidon

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