Occupational skin conditions are one of Europe’s top three registered occupational illnesses. Chemical, physical, and biological risk factors can cause skin disorders, but various individual (genetic) variables also play a role. The majority are caused by wet labor, chemical exposure at work, and excessive UV radiation from the sun. Contact dermatitis is the most common and can seriously impair an individual’s ability to function. Preventing occupational skin disorders necessitates a multifaceted strategy involving the dermatologist, occupational hygienist, occupational physician, and occupational safety and health specialist.