NON-SCARRING EPIDERMOLYSIS BULLOSA

TYPES

The following are the four most common types of non-scarring epidermolysis bullosa:

• EBS localized
• EBS generalized intermediate
• EBS with mottled pigmentation
• EBS generalized severe

SYMPTOMS

The signs and symptoms of non-scarring epidermolysis bullosa differ depending on its type. They may include:

• Nails that are very thick or do not form
• Skin thickening on the soles of the feet and palms
• Atrophic scarring (thin-appearing skin)
• Dental problems
• Painful, itchy skin
• Skin that is fragile and blisters easily, particularly on the feet and hands
• Blisters inside the mouth
• Scarring alopecia (hair loss)
• Milia (tiny white skin pimples)
• Dysphagia or difficulty swallowing

DIAGNOSIS

A clinical diagnosis established by a specialized dermatologist based on the presenting indications is frequently appropriate in the dominant subtypes of epidermolysis bullosa when an informative family tree is available.

In some countries, diagnostic techniques such as transmission electron microscopy (SEM) or immunofluorescence antigen mapping (IFM) on a skin biopsy of a newly generated blister are also available. Mutational analysis (blood testing of genes) is also accessible in certain places.

TREATMENT

Medication and surgery may be used if lifestyle adjustments and home care do not manage the signs and symptoms of non-scarring epidermolysis bullosa. Despite therapy, the illness often worsens, resulting in major complications and death.

Medications

Medications may help manage itching and pain and address problems, including bloodstream infection (sepsis). If the wounds show extensive infection, the healthcare professional may prescribe oral antibiotics (swollen lymph glands, weakness, and fever).

Surgery

Surgical intervention may be required. Some treatments for this ailment include:

• Placing a feeding tube
• Restoring mobility
• Widening the esophagus
• Grafting skin