Non-scarring epidermolysis bullosa, commonly known as epidermolysis bullosa simplex (EBS), is one of many genetic illnesses that causes the skin to be very fragile and to blister easily. Skin loss and blisters are caused by minor friction, such as scratching or rubbing. Even though this kind is non-scarring, scarring may develop in some instances.

Moreover, the blisters heal without leaving scars in mild instances, and the symptoms are comparable to those of eczema or psoriasis. Severe occurrences of this condition cause extensive blistering, which may lead to dehydration, infections, and other medical complications.


The following are the four most common types of non-scarring epidermolysis bullosa:

  • EBS localized
  • EBS generalized intermediate
  • EBS with mottled pigmentation
  • EBS generalized severe


The signs and symptoms of non-scarring epidermolysis bullosa differ depending on its type. They may include:

  • Nails that are very thick or do not form
  • Skin thickening on the soles of the feet and palms
  • Atrophic scarring (thin-appearing skin)
  • Dental problems
  • Painful, itchy skin
  • Skin that is fragile and blisters easily, particularly on the feet and hands
  • Blisters inside the mouth
  • Scarring alopecia (hair loss)
  • Milia (tiny white skin pimples)
  • Dysphagia or difficulty swallowing


A clinical diagnosis established by a specialized dermatologist based on the presenting indications is frequently appropriate in the dominant subtypes of epidermolysis bullosa when an informative family tree is available.

In some countries, diagnostic techniques such as transmission electron microscopy (SEM) or immunofluorescence antigen mapping (IFM) on a skin biopsy of a newly generated blister are also available. Mutational analysis (blood testing of genes) is also accessible in certain places.


Medication and surgery may be used if lifestyle adjustments and home care do not manage the signs and symptoms of non-scarring epidermolysis bullosa. Despite therapy, the illness often worsens, resulting in major complications and death.


Medications may help manage itching and pain and address problems, including bloodstream infection (sepsis). If the wounds show extensive infection, the healthcare professional may prescribe oral antibiotics (swollen lymph glands, weakness, and fever).


Surgical intervention may be required. Some treatments for this ailment include:

  • Placing a feeding tube
  • Restoring mobility
  • Widening the esophagus
  • Grafting skin

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