COMMON BRAND NAME(S): Nymalize
GENERIC NAME(S): NIMODIPINE
Description: Nimodipine is a calcium channel blocker that relaxes narrowed blood vessels in the brain near the area of bleeding so blood can flow more easily
Absorption: Rapidly absorbed from the GI tract. Bioavailability: Approx 13%. Time to peak plasma concentration: 1 hr.
Distribution: Crosses blood-brain barrier but concentrations in CSF are lower than those in plasma. Plasma protein binding: >95%.
Metabolism: Hepatically metabolised via CYP3A4 isoenzyme. Undergoes extensive first-pass metabolism.
Excretion: In faeces via bile, via urine (as metabolites). Terminal half-life: Approx 9 hr.