COMMON BRAND NAME(S): Tasigna
GENERIC NAME(S): NILOTINIB HCL
Description: Nilotinib is a potent inhibitor of BCR-ABL tyrosine kinase which can slow down or stop the growth of cancer cells.
Absorption: Food increases its bioavailability by approx 2-fold. Bioavailability: Approx 30%. Time to peak plasma concentration: Approx 3 hr.
Distribution: Plasma protein binding: Approx 98%.
Metabolism: Undergoes hepatic oxidation and hydroxylation via CYP3A4 isoenzyme.
Excretion: Via faeces (approx 93% as unchanged drug). Elimination half-life: Approx 17 hr.