COMMON BRAND NAME(S): Bystolic
GENERIC NAME(S): NEBIVOLOL HCL
Description: Nebivolol is a beta blocker used to lower heart rate, blood pressure and strain on the heart
Absorption: Rapidly absorbed from the GI tract. Time to peak plasma concentration: 1.5-4 hr.
Distribution: Volume of distribution: 8-12 L/kg. Plasma protein binding: Approx 98% (mainly to albumin).
Metabolism: Undergoes extensive hepatic metabolism via glucuronidation and via alicyclic and aromatic hydroxylation, N-dealkylation by CYP2D6 isoenzyme.
Excretion: Via urine and faeces (as metabolites). Elimination half-life: Approx 10 hr (nebivolol); approx 24 hr (hydroxy metabolites).