Description: Nateglinide is a nonsulfonylurea hypoglycaemic agent that aids in reducing post-meal increase of glucose levels.

Onset: Approx 20 min.

Duration: 4 hr.


Absorption: Rapidly absorbed; peak plasma concentrations within 1 hr (oral).

Distribution: Protein-binding: 98%, primarily to albumin.

Metabolism: Hepatic via hydroxylation followed by glucuronidation; converted to metabolites.

Excretion: Via urine (16% unchanged drug); faeces (10%). Elimination half-life: 1.5 hr.

  • Used for
    • High blood sugar control along with a proper diet and exercise program in people with type 2 diabetes
      • helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems and may also lessen your risk of a heart attack or stroke.
      • works by stimulating the body to produce more insulin which is a natural substance that allows the body to properly utilize sugar from the diet.


How to use nateglinide

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor


Taken by mouth; 1-30 minutes before each main meal; usually three times a day;

    • Minor side effects (if these symptoms persist or worsen, inform your doctor)
      • Weight gain


    • Serious side effects (inform your doctor immediately
      • Can cause low blood sugar (hypoglycemia)
        • chills, cold sweat, dizziness, drowsiness, shaking, fast heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger
      • Your physician may need to adjust your medications if you experience ymptoms of high blood sugar (hyperglycemia)
        • thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor


    • Severe allergic reactions are rare. Get immediate medical help if you notice the following:

    Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

    • Precautions:
      • Inform your doctor
        • Allergy to the medication or any allergies
        • Medical History of: kidney disease, liver disease, gout.


      • May cause blurring of vision, dizziness or drowsiness


      • Limit alcohol intake while taking this medication


      • Should only be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.


      • It is not known if this drug passes into breast milk. Before breast-feeding, consult your physician.



      Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.


      • Products that may interact with this medication include:
        • corticosteroids (such as prednisone), psychiatric medicines (such as olanzapine), fluoroquinolone antibiotics (such as ciprofloxacin)


      • Double check the labels on all medications you are currently taking especially cough-and-cold products since they may contain components that could affect your blodd sugar levels


      • Labratory tests that may be affected:

      urine tests for sugar or ketones

    • Overdose: If overdose is suspected, contact a poison control center or emergency room immediately.



      Check your blood sugar levels regularly as directed.


      Keep all medical appointments. Laboratory and/or medical tests (such as kidney/liver function tests, fasting blood glucose, hemoglobin A1c) should be performed periodically to check for side effects and monitor your response to treatment.


      Missed Dose

      If you miss a dose, skip that dose and resume your regular dosage schedule with your next meal. Do not double the dose to catch up.



      • Room temperature 77 degrees F (25 degrees C)
      • Brief storage at 59-86 degrees F (15-30 degrees C) is possible
      • Do not expose to light and moisture
      • Do not store in the bathroom
      • Keep all medications away from pets and children




      Available Brands:

      Starlix [ Novartis Healthcare ]

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