Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces hormones that cause inflammation and pain in the body. Pseudoephedrine is a decongestant that relieves nasal congestion by shrinking the blood vessels in the nasal passages.

This combination medication is used to treat symptoms caused by the common cold or flu. Symptoms may include stuffy nose, sinus congestion, headache, fever, and minor aches and pains. This medication may also be used in other conditions to be determined by your doctor.

Do not use this drug:

  • If you have used MAO inhibitor in the past 14 days. Interaction with this drug can be fatal.
  • In a long term or in high doses. Naproxen can increase risk of fatal heart attack or stroke.
  • Before or after a heart bypass surgery.

Common side effects may include:

  • Indigestion
  • Heartburn
  • Stomach Pain
  • Nausea
  • Diarrhea or Constipation
  • Warmth, Tingling, or Redness under your Skin
  • Sleep Problems (Insomnia)
  • Feeling Restless or Excited

Notify your doctor promptly if any of these symptoms persist or worsen.

Your doctor may have prescribed this medication because he or she judged that the benefit to you is greater than the risk of side effects.

Serious side effects may include:

  • Severe Allergic Reaction
  • Signs of a Heart Attack or Stroke such as Chest Pain Spreading to your Jaw or Shoulder, Sudden Numbness or Weakness on One Side of the Body, Slurred Speech, Feeling Short of Breath

Seek immediate medical attention if you experience any of these serious side effects.

If you experience any of the following, STOP using this drug promptly:

  • Swelling or Rapid Weight Gain
  • Severe Dizziness, Anxiety, Restless Feeling, or Nervousness
  • Shortness of Breath (even with Mild Exertion)
  • The First Sign of any Skin Rash
  • Signs of Stomach Bleeding–Bloody or Tarry Stools, Coughing Up Blood or Vomit that Looks Like Coffee Grounds
  • Kidney Problems–Little or No Urinating, Painful or Difficult Urination, Swelling in your Feet or Ankles, Feeling Tired or Short of Breath
  • Low Red Blood Cells (Anemia)–Pale Skin, Feeling Light-Headed or Short of Breath, Rapid Heart Rate, Trouble Concentrating
  • Liver Problems–Nausea, Upper Stomach Pain, Itching, Tired Feeling, Flu-Like Symptoms, Loss of Appetite, Dark Urine, Clay-Colored Stools, Jaundice (Yellowing of  the Skin or Eyes)
  • Severe Skin Reaction–Fever, Sore Throat, Swelling in your Face or Tongue, Burning in your Eyes, Skin Pain Followed by a Red or Purple Skin Rash that Spreads (Especially in the Face or Upper Body) and Causes Blistering and Peeling


Before taking this drug, tell your doctor or pharmacist:

  • If you are allergic to any content of this drug or if you have any other allergies.
  • Your medical condition or medical history.
  • If you have alcoholic dependence.
  • If you are pregnant or breastfeeding.



Drug interactions may either lessen the effectiveness of this drug or heighten the risk for severe side effects. It’s important to inform your doctor all the medication including prescription and non-prescription and herbal medicines you are taking or going to take.

Possible interactions with this drug are:

  • Alcohol
  • Bromocriptine
  • Cidofovir
  • Cocaine
  • Ketorolac
  • Methotrexate
  • Pemetrexed
  • Alendronate
  • Atomoxetine
  • Bretylium
  • Cyclopropane
  • Digoxin
  • Dyphylline
  • Flavocoxid
  • Furazolidone
  • Linezolid
  • Pamidronate
  • Probenecid
  • Procarbazine
  • Aspirin And Aspirin-Like Medicines
  • Maois Like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • Stimulant Medicines For Attention Disorders, Weight Loss, or to Stay Awake
  • Ergot Alkaloids like Dihydroergotamine, Ergonovine, Ergotamine, Methylergonovine
  • Medicines for Sleep During Surgery
  • Medicines for Blood Pressure, Chest Pain, Heart Disease, Irregular Heart Beat
  • Medicines for Depression, Anxiety, or Psychotic Disturbances
  • Medicines that Treat or Prevent Blood Clots like Warfarin
  • NSAIDS, Medicines for Pain and Inflammation like Ibuprofen or Naproxen
  • Other Medicines for Allergy, Cough, Cold, Fever or Pain
  • Other Medicine that Contains Naproxen or Pseudoephedrine
  • Herbals like St. John’s Wort, Ginkgo, Ginkgo Biloba

Call emergency hotline if someone has overdosed and has serious symptoms such as passing out or trouble breathing.

Symptoms of overdose may include:

  • Blurred Vision
  • Confusion
  • Decreased Urination
  • Hallucinations
  • Loss of Consciousness
  • Seizures
  • Severe Dizziness
  • Light-Headedness or Headache
  • Severe Drowsiness
  • Severe Nausea or Stomach Pain
  • Slow or Troubled Breathing
  • Unusual Bleeding or Bruising
  • Unusually Fast, Slow, or Irregular Heartbeat
  • Vomit that Looks like Coffee Grounds

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