COMMON BRAND NAME(S): Revia
GENERIC NAME(S): NALTREXONE HCL
Description: Naltrexone acts as a competitive antagonist at opioid receptor sites which prevents the opiate effects and decreases desire to take opiates.
Absorption: Well absorbed from the GI tract. Peak plasma concentrations after about 1 hr.
Distribution: 20% bound to plasma proteins.
Metabolism: Extensively metabolised in the lvier. Undergoes considerable 1st-pass metabolism and may undergo enterohepatic recycling.
Excretion: Via urine (as <1% unchanged drug and as metabolites). Elimination half-life: Approx 4 hr.