NALMEFENE

Nalmefene is a drug that is known as a specific opioid antagonist. It is structurally related to naltrexone. It affects opioid receptors in such a way that the cortico-mesolimbic functions are also changes and the level of alcohol consumption is lessened. It is being used to treat alcohol dependence and abuse. It is taken by mouth.

Uses

Nalmefene is a medicine that is used in the treatment of alcohol dependence.

Warnings

Nalmefene should not be given in people with the following conditions:

  • Recent opioid addiction
  • Acute opioid withdrawal symptoms
  • History of acute alcohol withdrawal syndrome
  • Severe liver and kidney problems
  • Concomitant use w/ opioid agonists (e.g. opioid analgesics, methadone) or partial agonists (e.g. buprenorphine)

Side Effects

Nalmefene may bring about the following side effects:

  • Psychiatric symptoms
  • Alcoholic psychosis
  • Alcohol withdrawal symptoms
  • Dizziness
  • Insomnia
  • Headache
  • Sleep disorder
  • Confusional state
  • Restlessness
  • Somnolence
  • Tremor
  • Attention disturbance
  • Paraesthesia
  • Hypoaesthesia
  • Fatigue
  • Asthenia
  • Malaise
  • Abnormal feeling
  • Hallucinations
  • Dissociation
  • Tachycardia
  • Palpitation
  • Nausea
  • Decreased appetite
  • Vomiting
  • Dry mouth
  • Diarrhoea
  • Decreased libido
  • Decreased weight
  • Muscle spasms
  • Hyperhidrosis

Precautions

Precautions

Take extra caution in people with the following conditions:

  • Patient with psychiatric comorbidity (e.g. major depressive disorder)
  • History of seizure disorders
  • Mild or moderate kidney or liver problems
  • Pregnancy
  • Breastfeeding

 

Interactions

Nalmefene may interact with the following medicines:

  • UGT2B7 enzyme inhibitors (e.g. diclofenac, fluconazole)
  • UGT2B7 enzyme inducers (e.g. dexamethasone, phenobarbital)
  • Opioids (e.g. cough medications, opioid analgesics)

Overdose & Brands

If you think, you may have taken more than the usual dose, seek medical help immediately.

 

Available Brand/s:

Revex

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