COMMON BRAND NAME(S): Synarel
GENERIC NAME(S): NAFARELIN ACETATE
Description: Nafarelin is a gonadotrophin-releasing hormone (GnRH) causes stimulation of gonadotrophin release in the initial phase (single dose) but with continued admin, stimulation is reversed resulting in the inhibition of gonadotrophin release.
Absorption: Rapidly absorbed (intranasal). Peak plasma concentrations within 20 min; bioavailability: About 3%.
Distribution: Protein-binding: 80%.
Metabolism: Metabolised by peptidases.
Excretion: SC admin: Via urine (as metabolites) and faeces (as unchanged drug).