COMMON BRAND NAME(S): Cardene
GENERIC NAME(S): NICARDIPINE HCL
Description: Nicardipine is a dihydropyridine Ca channel blocker that works by relaxing blood vessels so blood can flow more easily
Onset: Oral: 0.5-2 hr. IV: 10 min.
Duration: Immediate-release cap: ≤8 hr. Sustained-release cap: 8-12 hr. IV: ≤8 hr.
Absorption: Rapidly and completely absorbed from the GI tract. Bioavailability: Approx 35%. Time to peak plasma concentration: Immediate-release cap: 30-120 min; sustained-release cap: 60-240 min.
Distribution: Plasma protein binding: >95%.
Metabolism: Undergoes hepatic metabolism via CYP3A4 isoenzyme. Saturable extensive first-pass effect.
Excretion: Via urine and faeces mainly as inactive metabolites. Terminal half-life: Approx 8.6 hr.