NACARDIPINE - Watsons Health

NACARDIPINE

COMMON BRAND NAME(S): Cardene

GENERIC NAME(S): NICARDIPINE HCL

 

Description: Nicardipine is a dihydropyridine Ca channel blocker that works by relaxing blood vessels so blood can flow more easily

Onset: Oral: 0.5-2 hr. IV: 10 min.

Duration: Immediate-release cap: ≤8 hr. Sustained-release cap: 8-12 hr. IV: ≤8 hr.

Pharmacokinetics:

Absorption: Rapidly and completely absorbed from the GI tract. Bioavailability: Approx 35%. Time to peak plasma concentration: Immediate-release cap: 30-120 min; sustained-release cap: 60-240 min.

Distribution: Plasma protein binding: >95%.

Metabolism: Undergoes hepatic metabolism via CYP3A4 isoenzyme. Saturable extensive first-pass effect.

Excretion: Via urine and faeces mainly as inactive metabolites. Terminal half-life: Approx 8.6 hr.

  • Used for
    • Treatment of high blood pressure (hypertension) which aids in prevent strokes, heart attacks, and kidney problems.
    • It is a calcium channel blocker that works by relaxing blood vessels so blood can flow more easily.

 

  • Also used to prevent certain types of chest pain (angina)

 

How to use nicardipine

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor

 

  • Taken by mouth; With or without food; usually 3 times a day or as directed by your physician;
    • Minor side effects (if these symptoms persist or worsen, inform your doctor)
      • Dizziness, lightheadedness, headache, flushing, or swelling ankles/feet

     

    • Serious side effects (inform your doctor immediately)
      • fainting, fast/irregular/pounding heartbeat, vision changes, worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

     

    • Severe allergic reactions are rare. Get immediate medical help if you notice the following:

    Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

    • Precautions:
      • Inform your doctor
        • Allergy to the medication or any allergies

      Medical History of a certain structural heart problem (aortic stenosis), liver disease, kidney disease.

       

      • May cause dizziness or drowsiness

       

      • Should only be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.

       

      • It is uknown if this drug passes into breast milk. Before breast-feeding, consult your physician.

       

       

      Interactions:

      Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician.

       

      • Products that may interact with this medication include:
        • Cyclosporine, cimetidine, azole antifungals (such as itraconazole), macrolide antibiotics (such as erythromycin), rifamycins (such as rifabutin), St. John’s wort, drugs used to treat seizures (such as carbamazepine, phenytoin)

       

      Double check all the labels of the medications you are currently taking such as cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs for pain/fever) because they may contain ingredients that could increase your blood pressure or heart rate (such as pseudoephedrine, phenylephrine, ibuprofen, naproxen) that may increase your risk of side effects

    • Overdose: If overdose is suspected, contact a poison control center or emergency room immediately.

       

      Missed Dose

      If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose

       

      Storage

      • Room temperature
      • Do not expose to light and moisture
      • Do not store in the bathroom
      • Keep all medications away from pets and children

       

      Brands:

       

      Available Brands:

      Cardepine [ LR Imperial ]

    • Cardilon [ MedEthix ]Perdipine [ Astellas ]

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