COMMON BRAND NAME(S): Relafen
GENERIC NAME(S): NABUMETONE
Description: Nabumetone is a weak cyclooxygenase (COX) inhibitor that reduces prostaglandin levels which causes alleviation of pain and inflammation.
Absorption: Well absorbed from the GI tract (oral).
Distribution: Diffuses into synovial fluid; crosses the placenta; enters breast milk. Protein-binding: >99% (6-MNA).
Metabolism: Extensively hepatic; rapidly metabolised to 6-MNA; further metabolism by O-methylation and conjugation.
Excretion: Via urine (as inactive or conjugated metabolites). Elimination half-life of 6-MNA: 22-27 hr (adult), 25-34 hr (elderly).