Description: Nabumetone is a weak cyclooxygenase (COX) inhibitor that reduces prostaglandin levels which causes alleviation of pain and inflammation.


Absorption: Well absorbed from the GI tract (oral).

Distribution: Diffuses into synovial fluid; crosses the placenta; enters breast milk. Protein-binding: >99% (6-MNA).

Metabolism: Extensively hepatic; rapidly metabolised to 6-MNA; further metabolism by O-methylation and conjugation.

Excretion: Via urine (as inactive or conjugated metabolites). Elimination half-life of 6-MNA: 22-27 hr (adult), 25-34 hr (elderly).

  • Used for
    • Reduction of pain, swelling, and joint stiffness
    • It is a nonsteroidal anti-inflammatory drug (NSAID)


  • May also be used to treat gout attacks.


How to use nabumetone

  • Always refer to your doctors instructions before taking this medication. Duration and dosage will be determined by your medical condition and its response to the medication. Make sure to take this mediciation in the prescribed amount and time period even after symptoms disappear. Discontinuing the medication before completion of treatment may cause incomplete treatment of condition. If Symptoms persist, consult your doctor
  • Taken by mouth; With a full glass of water (8 oz or 240 ml), May be taken with food, milk or antacid to prevent stomach upset; usually once or twice a day


Take this medication by mouth as directed by your doctor, usually once or twice daily with a full glass of water (8 ounces or 240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take it with food, milk, or an antacid.

    • May rarely increase the risk for a heart attack or stroke
      • Should not be taken right before or after heart bypass surgery (CABG)
    • May seldom cause serious (rarely fatal) bleeding from the stomach or intestines


    Stop taking nabumetone and get medical help right away if you notice any of the following rare but serious side effects: bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.

      • Minor side effects (if these symptoms persist or worsen, inform your doctor)
        • Upset stomach, nausea, vomiting, constipation, diarrhea, gas, dizziness, drowsiness, or headache
      • May raise blood pressure.


      • Serious side effects (inform your doctor immediately)
        • Swelling of the hands or feet (edema), sudden or unexplained weight gain, hearing changes (such as ringing in the ears), mental/mood changes, difficult/painful swallowing, unusual tiredness, change in the amount of urine, unexplained stiff neck, bloody or black/tarry stools, persistent stomach/abdominal pain, vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, sudden vision changes, slurred speech.
        • May rarely cause serious (possibly fatal) liver disease
          • Dark urine, persistent nausea/vomiting, severe stomach/abdominal pain, yellowing eyes or skin.


      • Severe allergic reactions are rare. Get immediate medical help if you notice the following:

      Rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing

      • Precautions: 
        • Inform your doctor
          • Allergy to the medication or to aspirin or other NSAIDs (such as ibuprofen, naproxen, celecoxib) or any allergies
          • Medical History of asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), bleeding or clotting problems, growths in the nose (nasal polyps), heart disease (such as previous heart attack), high blood pressure, liver disease, stroke, stomach/intestinal/esophagus problems (such as bleeding, ulcers, recurring heartburn)


        • Kidney problems may occur with NSAID use
          • Problems are more likely to occur if you are dehydrated so keep hydrated


        • May cause dizziness or drowsiness


        • May cause stomach bleeding
          • Limit alcohol intake and do not smoke


        • May cause light sensitivity (photosensitivity)
          • Avoid prolonged sun exposure, tanning booths or sunlamps
          • Sunscreen and protective clothing are recommended when outdoors


        • Elderly may be more sensitive to side effects


        • Should be used when there is a clear need during pregnancy as it may harm an unborn baby. If you are planning to be pregnant or think you may be pregnant, discuss the risks and benefits of use with your doctor.


        • It is not known if this drug passes into breast milk. Before breast-feeding, consult your physician.







        Taking multiple drugs may affect how medications work and/or cause unwanted side effects. List down all the medications you are taking and inform your physician and pharmacist. Do not take, discontinue, or alter any dose of medications without prior approval of your physician


        • Products that may interact with this medication include:
          • aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, methotrexate, “water pills” (diuretics such as furosemide), anti-platelet drugs such as clopidogrel, “blood thinners” such as dabigatran/enoxaparin/warfarin, among others.


        • Double check all the labels of the medications you are currently taking as many drugs contain pain relievers/fever reducers such as aspirin, NSAIDs such as celecoxib, ibuprofen, ketorolac that may increase your risk of side effects


        If your doctor prescribed you low dose aspirin, continue to take it unless you are told otherwise

      • Overdose: If overdose is suspected, contact a poison control center or emergency room immediately.



        Non-drug treatment for arthritis that is approved by your doctor (such as weight loss if needed, strengthening and conditioning exercises) may help improve your flexibility, range of motion, and joint function. Consult your doctor for specific instructions.


        Missed Dose

        If you are prescribed this drug on a regular schedule (not just “as needed”) and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and As soon as you remember, take a regular dose or if the time of the next dose is near, wait for it before taking another dose and resume your usual schedule. Do not increase the dose to compensate for the missed dose.



        • Room temperature
        • Do not expose to light and moisture
        • Do not store in the bathroom
        • Keep all medications away from pets and children







        Available Brands:



        Also marketed as:

        Relifex [ SmithKline Beecham ]

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