DIAGNOSIS
Morvan disease symptoms were shown to be the same as limbic encephalitis (LE). It includes sleeplessness, hallucinations, and confusion, along with psychosis and dementia, which are all CNS symptoms. Each of these conditions is linked with thymoma and can be paraneoplastic. Hence, a differential diagnosis will need to be conducted.
Moreover, VGKC antibodies have recently been discovered in LE individuals, bolstering the theory that LE and Morvan Syndrome are linked. To assess which of the two illnesses the person has, a variety of tests can be employed.
TREATMENT
The treatment choices in the majority of the confirmed incidents were quite comparable. The most often utilized treatment method for treating Morvan Syndrome has been plasmapheresis alone or in association with steroids, occasionally combined with azathioprine and thymectomy. Nevertheless, while failure reactions to steroids and further plasmapheresis were documented, it does not always succeed. In one instance, intravenous immunoglobulin proved successful.
The remarkable reaction to high-dose oral prednisolone combined with pulses of methylprednisolone for one patient, with nearly total elimination of symptoms in a brief period, should prompt corticosteroids to be considered.
