COMMON BRAND NAME(S): Primacor
GENERIC NAME(S): MILRINONE LACTATE
Description: Milrinone is a selective phosphodiesterase III inhibitor with positive inotropic and vasodilator activity. It selectively inhibits cyclic adenosine monophosphate (cAMP) phosphodiesterase activity in cardiac and vascular muscles resulting in increased intracellular concentrations of cAMP. It also acts directly on vascular smooth muscle.
Onset: IV: 5-15 minutes.
Distribution: Protein binding: About 70%. Volume of distribution at steady-state: 0.32-0.45 L/kg.
Metabolism: About 12% metabolised hepatically.
Excretion: Eliminated via urine (85% as unchanged drug). Elimination half life: About 2.5 hr.