Description: Meropenem is a synthetic carbapenem β-lactam antibiotic that exerts its bactericidal activity by inhibiting bacterial cell wall synthesis in gm+ve and gm-ve bacteria through binding to several penicillin-binding proteins (PBPs).


Absorption: Time to peak plasma concentration: Approx 1 hr (tissue); 2-3 hr (CSF).

Distribution: Widely distributed into body tissues and fluids including CSF and bile. Volume of distribution: 15-20 L (adult); 0.37-0.49 L/kg (childn). Plasma protein binding: Approx 2%.

Metabolism: Hepatically hydrolysed to one inactive metabolite (ICI-213689).

Excretion: Via urine (approx 70% as unchanged drug; approx 28% as inactive metabolite); faeces (2%). Mean plasma elimination half-life: Approx 1 hr.

Meropenem is used to treat a wide variety of bacterial infections. This medication is known as a carbapenem-type antibiotic. It works by stopping the growth of bacteria.


How to use meropenem intravenous

This medication is given by injection into a vein, usually every 8 hours or as directed by your doctor. The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight.


If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.


Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.


Continue to use this medication until the full prescribed treatment period is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.


Tell your doctor if your condition persists or worsens.

Swelling, redness, pain, or soreness at the injection site may occur. This medication may also infrequently cause upset stomach, headache, nausea, vomiting, constipation, or diarrhea. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.


Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.


Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, hearing changes (e.g., decreased hearing, ringing in the ears), mental/mood changes (e.g., confusion), swollen tongue, numb/tingling skin.


Get medical help right away if any of these rare but very serious side effects occur: seizures, unusual weakness.


This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse. Tell your doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.


Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.


A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Before using meropenem, tell your doctor or pharmacist if you are allergic to it; or to penicillins or cephalosporins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.


Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, stomach/intestinal diseases (e.g., colitis).


This drug may rarely cause headaches, numb/tingling skin, or seizures. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.


Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).


Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.


Tell your doctor if you are pregnant before using this medication.


This medication passes into breast milk. Consult your doctor before breast-feeding.





Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.


Some products that may interact with this drug include: live bacterial vaccines, valproic acid and related drugs (such as divalproex sodium, sodium valproate), other antibiotics.


Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.

If overdose is suspected, contact a poison control center or emergency room immediately.



Laboratory and/or medical tests (e.g., complete blood count, kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.


Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist immediately to establish a new dosing schedule. Do not double the dose to catch up.



Consult the package instructions or your pharmacist for storage details. Keep all medicines away from children and pets.


Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.





Available Brands

Aropen [ Aristopharma ]

Canem [ Cachet Pharma ]

Dexpenem [ Gracio Med ]

Erodium [ Yeluri ]

Hospira Meropenem Trihydrate [ Hospira ]

Menem IV [ Juventis Pharma ]

Mepenem [ Singapore Pharmawealth Lifesciences ]

Meroget [ Getz Pharma ]

Meromax [ YSS ]

Meromax IV [ Shenzhen Haibin ]

Meronem [ AstraZeneca ]

Merop [ Biomedis ]

Meropen [ Swiss Parenterals ]

Meropevex [ Reyoung Pharma ]

Merosea [ Protech Biosystems ]

Merovex 500/Merovex 1000 [ VE Pharma ]

Merozan [ Demo S. A. ]

Ropen [ LBS ]

Ropenem [ Sherrington Pharma ]

Supenem [ Macheal Lab ]


Also marketed as:

Merix [ Xeno ]                                                                                   Meropenex [ United Biotech ]

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