Mardepine is used in the following conditions:

  • Hypertension: Nicardipine is commonly prescribed to lower blood pressure in patients with hypertension. It works by relaxing and widening the blood vessels, which helps to reduce the resistance against blood flow. By lowering blood pressure, nicardipine can help to decrease the risk of heart attack, stroke, and other complications associated with hypertension.
  • Angina: Nicardipine is also used to relieve symptoms of angina, which is chest pain or discomfort caused by reduced blood flow to the heart muscle. By dilating the coronary arteries, nicardipine improves blood flow to the heart, relieving angina symptoms such as chest pain or pressure.
  • Raynaud’s Phenomenon: In some cases, nicardipine may be prescribed to treat Raynaud’s phenomenon, a condition characterized by spasms in the small blood vessels of the fingers and toes. By improving blood flow, nicardipine can help to reduce the frequency and severity of Raynaud’s attacks.

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Mardepine in people with the following conditions:

  • Hypersensitivity: Nicardipine should not be used in individuals who have a known hypersensitivity or allergic reaction to the medication or any of its components.
  • Severe aortic stenosis: Nicardipine is contraindicated in individuals with severe aortic stenosis, a condition characterized by narrowing of the aortic valve in the heart. The medication can further obstruct blood flow through the narrowed valve, potentially worsening symptoms and leading to serious complications.
  • Acute myocardial infarction: Nicardipine is contraindicated in the acute phase of a myocardial infarction (heart attack) where there is evidence of left ventricular dysfunction, low blood pressure, or cardiogenic shock. It is important to stabilize the patient’s condition before considering the use of nicardipine.
  • Unstable angina: Nicardipine is contraindicated in patients with unstable angina, which refers to chest pain or discomfort that occurs at rest or with minimal exertion and is associated with a high risk of a heart attack. Other treatment options should be considered in such cases.
  • Severe hepatic impairment: Nicardipine should be used with caution or avoided in individuals with severe liver impairment, as the medication is primarily metabolized in the liver. Impaired liver function can affect the metabolism and elimination of nicardipine, leading to increased drug levels and a higher risk of adverse effects.

Mardepine may have the following side effects:

  • Flushing or feeling of warmth: Nicardipine can cause a temporary sensation of warmth or flushing of the skin, particularly in the face and neck.
  • Headache: Some individuals may experience headaches while taking Nicardipine. These headaches are usually mild and temporary.
  • Dizziness or lightheadedness: Nicardipine can cause a drop in blood pressure, leading to feelings of dizziness or lightheadedness. It is important to get up slowly from a sitting or lying position to minimize this effect.
  • Swelling: Nicardipine may cause fluid retention, resulting in swelling of the ankles, feet, or hands. If you notice significant swelling, it is important to inform your healthcare provider.
  • Nausea or stomach discomfort: Some individuals may experience gastrointestinal symptoms such as nausea, stomach pain, or indigestion.
  • Fatigue: Nicardipine can sometimes cause feelings of tiredness or fatigue.
  • Rapid heartbeat or palpitations: In rare cases, Nicardipine may cause an increase in heart rate or irregular heartbeats, which should be reported to a healthcare professional.

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.


Take extra caution in patients with the following medical conditions:

  • Pregnancy and breastfeeding: Nicardipine should be used with caution during pregnancy and breastfeeding. It is important to discuss the potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant, or if you are breastfeeding.
  • Driving and operating machinery: Nicardipine may cause dizziness or lightheadedness, which can impair your ability to drive or operate machinery safely. It is important to be cautious and avoid such activities if you experience these side effects.
  • Other medical conditions and medications: Inform your healthcare provider about any other medical conditions you have, as well as any other medications, supplements, or herbal products you are taking. Nicardipine may interact with certain medications or worsen certain medical conditions, so it is important to disclose this information to your healthcare provider.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Mardepine may interact with the following medicines:

  • Grapefruit and grapefruit juice: As mentioned earlier, grapefruit and grapefruit juice can interfere with the metabolism of Nicardipine, leading to increased levels of the medication in the body. This can potentially increase the risk of side effects. It is best to avoid grapefruit products while taking Nicardipine.
  • Other blood pressure medications: Combining Nicardipine with other blood pressure medications, such as beta-blockers, ACE inhibitors, or diuretics, may enhance the blood pressure-lowering effects. However, careful monitoring is necessary to prevent excessive lowering of blood pressure.
  • CYP3A4 inhibitors: Nicardipine is metabolized by an enzyme called CYP3A4. Medications that inhibit this enzyme, such as certain antifungal medications (ketoconazole, itraconazole), HIV protease inhibitors, and some antibiotics (clarithromycin, erythromycin), can increase the levels of Nicardipine in the body, potentially leading to an increased risk of side effects. Your healthcare provider may need to adjust the dosage of Nicardipine if you are taking any of these medications.
  • CYP3A4 inducers: Conversely, medications that induce the activity of CYP3A4, such as certain anticonvulsants (phenytoin, carbamazepine), rifampin (an antibiotic), and St. John’s wort, can decrease the levels of Nicardipine in the body, potentially reducing its effectiveness. Dosage adjustments may be necessary in such cases.
  • Other medications: Nicardipine may interact with other medications, such as certain antiarrhythmics, anticoagulants, and statins. It is important to inform your healthcare provider about all the medications you are taking to ensure safe and effective use of Nicardipine.
    Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

  • Mardepine

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