Mantle Cell Lymphoma is a malignancy that originates from the mantle zone area of the lymph nodes than gives rise to poorly functioning B cell lymphocytes which are responsible for the immunity of an individual. It is a very slow-growing tumor and could sometimes pass off as normal lymphocytes in a bone marrow smear to an untrained eye. It has a very unfavorable character in that this type of lymphoma has a high tendency to recur even if the patient is considered to be free of the condition.
Mantle cell lymphoma currently affects 6% of the worldwide population. Commonly found in the middle aged to older men than in women and is believed to be caused by a displacement of the loci between chromosome 11 and 14. Due to this “mix-up,” there is also aberrant cyclin D1 which is responsible for the regulating cell growth, thereby causing overproduction of B cells.