Description: Loperamide acts directly on intestinal wall muscles to inhibit peristalsis and prolongs transit time. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.

Onset: 0.5-1 hr.


Absorption: Absorbed from the GI tract. Peak plasma concentrations achieved after 2.5 hr (oral solution) or 4-5 hr (capsule).

Excretion: Excreted in the urine (<2%) and faeces (30% as unchanged drug). Elimination half life of around 10.8 hr.

This medication treats sudden diarrhea by slowing down the movement of the gut. This decreases the number of bowel movements and makes the stool less watery. Loperamide is also used in patients who have undergone an ileostomy to reduce the amount of discharge. It is also used to treat on-going diarrhea in people with inflammatory bowel disease but it does not treat the disease.

How to use loperamide

If you are using the over-the-counter product to self-treat, read all the directions on the product package before taking this medication. If your doctor has prescribed this medication, follow your doctor’s directions and the directions on your prescription label. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth, usually after each loose stool, or as directed by your doctor. Dosage is based on your condition and response to therapy. In children, dosage is also based on age and weight. Adults should not use more than 8 milligrams in 24 hours if self-treating, or 16 milligrams if under a doctor’s direction.

If you are taking the chewable tablet, take this medication on an empty stomach. The chewable tablets should be chewed thoroughly before swallowing.

If you are using the rapidly dissolving tablets, dry your hands before opening the blister pack to carefully remove a tablet. Do not push the tablet through the blister pack. Place the tablet on the tongue, allow it to dissolve completely, then swallow it with saliva. Do not crush, split, or break the tablet before taking it. Do not remove the tablet from the blister pack until just before taking. No water is needed to take this medication.

Diarrhea can cause a serious loss of body water (dehydration). Drink plenty of fluids and minerals (electrolytes) to replace what is lost. Tell your doctor immediately if you develop signs of dehydration (e.g., extreme thirst, decreased urination, muscle cramps, weakness, fainting). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.

Tell your doctor if your diarrhea does not improve after 2 days, if your condition worsens, or if you develop new symptoms. If you develop blood in the stool, fever, or an uncomfortable fullness/swelling of the stomach/abdomen, or if you think you may have a serious medical problem, seek immediate medical attention.

If you are taking this medication under your doctor’s direction for ongoing diarrhea, tell your doctor if your diarrhea continues after 10 days of treatment.

Contact your doctor promptly if any of these effects persist or worsen:

  • Dizziness
  • Drowsiness
  • Tiredness
  • constipation

Stop taking this medication and seek immediate medical attention if any of these unlikely but serious side effects occur:

  • severe constipation/nausea/vomiting
  • stomach/abdominal pain
  • uncomfortable fullness of the stomach/abdomen

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including:

  • Rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

  • Allergic reaction to this medication
  • Patients with certain medical conditions such as stomach/abdominal pain without diarrhea or bowel obstruction (e.g., ileus, megacolon, abdominal distention)
  • safe use of this medicine if you have phenylketonuria (PKU).
  • Do not use this anti-diarrhea product after recent antibiotic use
  • Patients with medical history of: black/tarry stool, blood/mucus in your stool, high fever, HIV infection/AIDS, liver problems, certain stomach/intestinal infections (e.g., Salmonella, Shigella), certain type of bowel disease (acute ulcerative colitis).
  • This drug may make you dizzy or drowsy
  • children because they may be more sensitive to the drowsiness effect
  • Do not use in children younger than 6 years unless directed by your doctor. Children are at higher risk for dehydration
  • This medication should be used only if clearly needed during pregnancy
  • Consult your doctor before breast-feeding

Consult your doctor regarding the precautions mentioned above.



This drug should not be used with pramlintide. Tell your doctor or pharmacist before starting loperamide if you are currently using pramlintide.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • recent/current antibiotic use
  • drugs that can cause constipation (e.g., anticholinergics, antispasmodics, potent narcotic pain medicines, certain antihistamines, tricyclic antidepressants)
  • cholestyramine
  • quinidine
  • ritonavir
  • saquinavir

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

If overdose is suspected, contact a poison control center or emergency room immediately.


If your doctor has prescribed this medication for you, do not share it with others.

Missed Dose

If you are taking this drug on a regular schedule (not “as needed”) and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Refer to storage information printed on the bottle for the exact temperature range. If you have any questions about storage, ask your pharmacist. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.



Available Brands:

Diaperyl [ Medi-Rx ]                                                                                            Diatabs [ United Lab ]

Imodium [ Johnson & Johnson ]                                                                        Lomotil [ Johnson & Johnson ]

Loniper [ Foramen ]                                                                                            Lormide [ Westmont ]

RiteMED Loperamide [ RiteMED ]

Also marketed as:

Bryper [ Brymar Pharma ]                                                                                  Diamide [ Filadams ]

Diastop [ Flamingo ]                                                                                             Doctor’s Loperamide [ Doctors ]

Gastromed [ Euro-Med ]                                                                                     LBX [ Novagen Pharma ]

Lodarest [ Le Jumont ]                                                                                        Lorban [ Medhaus ]

Tymedon [ Ace ]

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