COMMON BRAND NAME(S): Prinivil, Zestril
GENERIC NAME(S): LISINOPRIL
Description: Lisinopril promotes vasodilation and BP reduction by competitively inhibiting ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion.
Onset: 1-2 hr.
Duration: 24 hr
Absorption: Absorbed slowly and incompletely from the GI tract. Absolute bioavailability: Decreased by approx 16% w/ heart failure. Time to peak plasma concentration: Approx 7 hr.
Distribution: It crosses the placenta. Plasma protein binding: Not significantly bound (25%).
Excretion: Via urine (as unchanged drug). Elimination half-life: 12 hr.