LATANOPROST + TIMOLOL

Latanoprost, a prostaglandin F2 analogue, is a selective prostanoid FP receptor agonist that lowers intraocular pressure by increasing aqueous humour uveoscleral outflow. Timolol, a non-selective adrenergic receptor antagonist, lowers intraocular pressure by reducing ciliary epithelial production of aqueous humour.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Uses

Latanoprost + Timolol is used in the following conditions:

Ocular hypertension
Open-angle glaucoma

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Latanoprost + Timolol in people with the following conditions:

Reactive airway disease
Existing or history of bronchial asthma
Severe chronic obstructive pulmonary disease (COPD)
Sinus bradycardia
Sick sinus syndrome
Sino-atrial block
2nd- or 3rd-degree atrioventricular block (not controlled with a pacemaker)
Overt cardiac failure
Cardiogenic shock
Active herpes simplex keratitis
History of recurrent herpetic keratitis specifically associated with prostaglandin analogues

Side Effects

Latanoprost + Timolol may have the following side effects:

Choroidal detachment (post-filtration procedures)
Increased iris pigmentation
Eyelid skin and eyelash changes (increased length, darkening and thickening of the eyelashes)
Anaphylactic reactions
Bacterial keratitis
Cystoid macular edema
Eye pain or irritation
Blepharitis
Blurred vision
Corneal disorder
Conjunctivitis
Eye hyperemia
Dizziness
Headache
Rash

Potentially Fatal:

Cardiac failure
Bronchospasm (in patients with asthma)

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

History of atopy or severe anaphylaxis to allergens
1st-degree heart block
Heart failure
Orthostatic hypotension
Severe peripheral circulatory disturbance or disorders
Severe forms of Raynaud’s syndrome
Mild or moderate chronic obstructive pulmonary disease (COPD)
Diabetes (especially labile diabetes)
Hyperthyroidism
Corneal diseases
Other types of glaucoma
Inflammatory
Neovascular or chronic angle-closure glaucoma
Open-angle glaucoma of pseudophakic patients
Pigmentary glaucoma
Closed-angle glaucoma (as monotherapy)
History of herpetic keratitis
Active intraocular inflammation
Aphakic patients
Pseudophakic patients with torn posterior lens capsule
Risk factors for macular edema
Myasthenia gravis
Patients undergoing surgery

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Latanoprost + Timolol may interact with the following medicines:

Oral or other topical βeta-adrenergic blockers

Latanoprost:

Prostaglandin analogues

Timolol:

Oral calcium channel blockers
Guanethidine
Antiarrhythmics
Amiodarone
Digitalis glycosides
Parasympathomimetics
Narcotics
Monoamine oxidase inhibitors
Quinidine
Fluoxetine
Paroxetine
Epinephrine
Clonidine
Anti-diabetic agents

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms:

Latanoprost:

Ocular irritation
Conjunctival hyperemia

Timolol (systemic):

Bradycardia
Hypotension
Bronchospasm
Cardiac arrest

If an overdose is suspected, call your health care provider immediately.

Available brands:

Astimol
Xalacom
Xalavist Plus