Isocarboxazid is under the drug classification of monoamine oxidase (MAO) inhibitors. It is a non-selective blocker of monoamine oxidase type A and B, which are involved in the elevation of the concentration of neurotransmitters such as;  epinephrine, norepinephrine, dopamine, and serotonin. This  hydrazine derivative irreversibly binds to MAO resulting in the breakdown of these neurotransmitters.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist.

Isocarboxazid is used in the following conditions:

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.  

Do not use Isocarboxazid in people with the following conditions:

  • Cerebrovascular disorders
  • Severe CV disease
  • Actual or suspected pheochromocytoma. 
  • Hepatic
  • Severe renal impairment

Isocarboxazid may have the following side effects:

  • Orthostatic hypotension
  • Associated in some patients with disturbances in cardiac rhythm
  • Peripheral edema
  • Complaints of dizziness
  • Dry mouth
  • Nausea and vomiting
  • Constipation
  • Blurred vision
  • Insomnia
  • Drowsiness
  • Weakness and fatigue
  • Infrequent reports of mild headaches
  • Sweating
  • Paraesthesia
  • Peripheral neuritis
  • Hyperreflexia
  • Agitation
  • Overactivity
  • Muscle tremor
  • Confusion and other behavioural changes
  • Difficulty in micturition
  • Impairment of erection and ejaculation
  • Skin rashes
  • Increased appetite
  • Weight gain
  • Blood dyscrasias (e.g. purpura, granulocytopenia)

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Patient with cardiovascular disease
  • Diabetes mellitus or blood dyscrasias
  • Avoid abrupt withdrawal
  • Mild to moderate renal impairment
  • Elderly
  • Debilitated patients. 
  • Pregnancy
  • Lactation

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Isocarboxazid may interact with the following medicines:

  • Clomipramine
  • Desipramine
  • Imipramine
  • Butriptyline
  • Bortriptyline 
  • Amphetamines
  • Metaraminol
  • Fenfluramine
  • Ephedrine
  • Phenylpropanolamine
  • Dopamine
  • Levodopa
  • Barbiturates
  • Phenothiazines

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following:

  • Dizziness
  • Ataxia
  • Irritability
  • Hypotension or hypertension
  • Tachycardia
  • Pyrexia
  • Psychotic manifestations
  • Convulsions
  • Resp depression and coma ·          

Seek medical help immediately. 

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