INDACATEROL

COMMON BRAND NAME(S): Arcapta Neohaler

GENERIC NAME(S): INDACATEROL MALEATE

 

Description: Indacaterol is a long acting β2-adrenergic agonist that relaxes the bronchial smooth muscle. It selectively acts on β2-receptor in the lungs and w/ little effect on heart rate.
Onset: 5 min.
Duration: 24 hr.
Pharmacokinetics: 
Absorption: Bioavailability: 43%. Time to peak plasma concentration: Approx 15 min.
Distribution: Plasma protein binding: Approx 95%.
Metabolism: Metabolised via hydroxylation mainly by CYP3A4 isoenzyme and to a lesser extent, CYP1A1 and CYP2D6 isoenzymes; via glucuronidation by uridine diphosphate-glucuronosyltrasnsferase (UGT) 1A1.
Excretion: Via faeces (approx 90%) and urine (<2% as unchanged drug). Elimination half-life: 40-56 hr.

Indacaterol is used if your breathing problems are not controlled with other medication (such as a quick-relief inhaler). It works in the airways by relaxing muscles and opening air passages to improve breathing and treat trouble breathing and wheezing. This medication should not be used for severe/sudden breathing problems.

 

How to use indacaterol inhalation

Read the Medication Guide and the Instructions for Use provided by your pharmacist before you start using indacaterol and each time you get a refill. Learn and follow the directions for proper use and care of the inhaler device and this medication. If you have any questions, ask your healthcare provider or pharmacist.

 

Indacaterol comes in a capsule. Do not swallow these capsules. Inhale the contents of the capsule by mouth using the inhaler device as directed by your doctor, usually one capsule once daily. Indacaterol must always be used with its own special inhaler device. Always discard your old inhaler device and use the new inhaler device that you get each time you refill your indacaterol prescription. Do not use a “spacer” device with the inhaler.

 

Leave the capsule sealed in the blister card until just before use. Wash and completely dry hands before touching the capsules. Inhale the capsule contents as directed to make sure you inhale all of the drug. Be sure to inhale rapidly and deeply through the mouthpiece when using this drug. Do not exhale into the inhaler.

 

If you are using other inhalers at the same time, wait at least 1 minute between the use of each medication.

 

Using too much indacaterol or using it too often may make the drug work less well and increase the risk of serious side effects. Do not use more than the recommended dose or use this drug more often than prescribed. If you are using a quick-relief inhaler on a regular schedule (such as 4 times a day), you should stop the regular schedule and continue using your quick-relief inhaler only as needed for severe/sudden breathing problems. Do not stop or decrease the dose of your other prescribed medications (including inhaled corticosteroids such as beclomethasone) without your doctor’s approval.

 

Learn which of your inhalers you should use every day and which you should use if your breathing suddenly worsens (quick-relief drugs). Ask your doctor ahead of time what you should do if you have new or worsening cough or shortness of breath, wheezing, increased sputum, waking up at night with trouble breathing, if you use your quick-relief inhaler more often, or if your quick-relief inhaler does not seem to be working well. Learn when you can treat sudden breathing problems by yourself and when you must get medical help right away.

 

Tell your doctor right away if your symptoms do not improve or if they worsen.

Rarely, serious (sometimes fatal) breathing problems have happened to people with asthma using a long-acting inhaled beta agonist.

Tell your doctor or pharmacist promptly if any of these effects persist or worsen:

 

  • Shakiness (tremor)
  • Nausea
  • Headache
  • cough

 

 

This medication may raise your blood pressure.

 

Tell your doctor right away if you muscle weakness/cramping or increased thirst/urination.

 

Get medical help right away if you have any very serious side effects, including:

 

  • fast/pounding/irregular heartbeat
  • severe dizziness
  • fainting

 

 

A very serious allergic reaction to this drug is rare.

 

Rarely, indacaterol can cause a worsening of breathing problems (paradoxical bronchospasm) that may be life-threatening.

 

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

 

  • Allergic reaction to this medication
  • Patients with medical history of:

 

  • Diabetes
  • heart disease (such as irregular heartbeat, angina)
  • high blood pressure
  • overactive thyroid (hyperthyroidism)
  • seizures

 

  • QT prolongation (affected heart rythm) from this drug. Older adults may be more sensitive to this.
  • Tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before having surgery.
  • This medication should be used only when clearly needed during pregnancy
  • Consult your doctor before breast-feeding

Consult your doctor regarding the precautions mentioned above.

 

Interactions

 

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Overdose

 

This medication will not work and may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: fast/irregular heartbeat, severe nervousness, severe muscle cramps.

 

Notes

Do not share this medication with others.

 

Avoid substances that can worsen breathing problems by causing irritation or allergic reaction, such as smoke, pollen, pet dander, dust, and mold.

 

Talk with your doctor about getting a yearly flu shot.

 

Laboratory and/or medical tests (such as blood pressure, heart rate, lung function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

 

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

 

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

 

Brands


Available Brands

Onbrez Breezhaler [ Novartis Pharma Stein ]

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