IMIPEN

Do not use Imipen in people with the following conditions:

• Hypersensitivity
• History of severe allergic reactions: If you have a history of severe allergic reactions, including anaphylaxis, to imipenem, cilastatin, or other beta-lactam antibiotics, the use of this medication is contraindicated
• Previous serious skin reactions: If you have experienced severe skin reactions, such as Stevens-Johnson syndrome or toxic epidermal necrolysis, in the past while taking imipenem and cilastatin or other beta-lactam antibiotics, this medication should be avoided
• Seizure disorders: Imipenem and cilastatin can lower the seizure threshold, meaning it may increase the risk of seizures in individuals with a history of seizure disorders. In such cases, caution should be exercised, and the use of this medication should be carefully evaluated
• Known or suspected bacterial meningitis: Imipenem and cilastatin are not indicated for the treatment of bacterial meningitis. If bacterial meningitis is suspected, alternative antibiotics specifically used for treating meningitis should be considered.

Imipen may have the following side effects:

• Gastrointestinal effects: These can include nausea, vomiting, diarrhea, and abdominal pain. It’s essential to stay hydrated and report any severe or persistent symptoms to your healthcare provider.
• Skin reactions: Rashes, itching, and hives may occur. If you develop a severe skin reaction or any signs of an allergic reaction, such as swelling of the face, lips, or throat, seek immediate medical attention.
• Central nervous system effects: Some individuals may experience headache, dizziness, or confusion while taking imipenem and cilastatin. If these symptoms are severe or persistent, it’s important to inform your healthcare provider
• Injection site reactions: Pain, redness, and swelling at the site of injection may occur. Inform your healthcare provider if you notice any unusual or severe reactions at the injection site
• Changes in laboratory test results: Imipenem and cilastatin can affect certain laboratory test results, such as liver function tests or blood cell counts. Your healthcare provider will monitor these parameters during treatment
• Allergic reactions: Although rare, serious allergic reactions can occur with imipenem and cilastatin. Seek immediate medical attention if you experience symptoms such as difficulty breathing, chest tightness, or swelling of the face, lips, or tongue

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

• Allergies: Inform your healthcare provider about any known allergies or hypersensitivity to imipenem, cilastatin, or any other beta-lactam antibiotics. This is crucial as allergic reactions can occur and may be severe
• Kidney problems: If you have kidney disease or impaired kidney function, your healthcare provider may need to adjust the dosage of imipenem and cilastatin. Regular monitoring of kidney function may be necessary
• Seizure disorders: Imipenem and cilastatin can lower the seizure threshold, potentially increasing the risk of seizures. If you have a history of seizure disorders or are at an increased risk, your healthcare provider will carefully evaluate the benefits and risks of using this medication
• Pregnancy and breastfeeding: It is important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Imipenem and cilastatin may be used during pregnancy or breastfeeding if the benefits outweigh the potential risks, but this decision will be made by your healthcare provider
• Other medications: Inform your healthcare provider about all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements. Some medications may interact with imipenem and cilastatin, potentially affecting their effectiveness or increasing the risk of side effects
• Bacterial meningitis: Imipenem and cilastatin are not indicated for the treatment of bacterial meningitis. If meningitis is suspected, other antibiotics specifically used for treating meningitis should be considered.

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Imipen may interact with the following medicines:

• Probenecid: Probenecid may decrease the elimination of imipenem, leading to increased levels of the medication in the body. This can increase the risk of side effects. Your healthcare provider may need to adjust the dosage of imipenem and cilastatin if you are taking probenecid.
• Valproic acid: Imipenem and cilastatin can lower the levels of valproic acid in the body, potentially reducing its effectiveness in treating certain conditions. If you are taking valproic acid, your healthcare provider may need to closely monitor your condition and adjust the dosage accordingly.
• Anticoagulants: Imipenem and cilastatin can interact with certain anticoagulant medications, such as warfarin, potentially increasing the risk of bleeding. Regular monitoring of blood clotting parameters may be necessary if you are taking both medications.
• Other antibiotics: Imipenem and cilastatin should not be used concurrently with other beta-lactam antibiotics, as they may compete for the same receptors and reduce the effectiveness of both medications.
• Vaccines: Imipenem and cilastatin may decrease the effectiveness of certain vaccines. It is recommended to complete any necessary vaccinations before starting treatment with this medication. Inform your healthcare provider if you are scheduled to receive any vaccines while taking imipenem and cilastatin.

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

If you suspect an overdose, contact your doctor right away.

Available Brands:

• Imipen