ILOPERIDONE

Iloperidone is an atypical antipsychotic having antagonistic action at dopamine D2 and serotonin (5-HT2), D3, and 1-adrenergic receptors. The combined antagonism is expected to alleviate psychosis’ unpleasant symptoms and reduce the occurrence of extrapyramidal side effects.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Uses

Iloperidone is used in the following conditions:

Schizophrenia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Warnings

Do not use Iloperidone in people with the following conditions:

Congenital long QT syndrome
History of cardiac arrhythmias
Recent myocardial infarction
Uncompensated heart failure
Concomitant use with QTc-prolonging drugs

Side Effects

Iloperidone may have the following side effects:

Altered cardiac conduction and QTc interval prolongation
Leucopenia
Neutropenia
Central Nervous System depression
Dyslipidemia
Esophageal dysmotility and aspiration
Suicidal ideation
Orthostatic hypotension
Dizziness
Tachycardia
Syncope
Seizures
Extrapyramidal symptoms
Pseudoparkinsonism
Acute dystonic reactions
Akathisia
Tardive dyskinesia
Falls due to somnolence
Motor/sensory instability
Hyperprolactinemia
Weight gain
Impaired core body temperature regulation
Withdrawal symptoms
Priapism
Anemia
Palpitations
Blurred vision
Conjunctivitis
Nausea
Dry mouth
Diarrhea
Abdominal discomfort
Fatigue
Lethargy
Edema
Weight decreased
Increased appetite
Dehydration
Hypokalemia
Arthralgia
Myalgia
Musculoskeletal stiffness
Muscle spasms
Tremor
Paresthesia
Restlessness
Aggression
Delusion
Hostility
Libido decreased
Urinary incontinence
Ejaculation disorder
Erectile dysfunction
Amenorrhea
Gynecomastia
Galactorrhea
Nasal congestion
Nasopharyngitis
Upper respiratory tract infection
Dyspnea
Rash
Pruritus
Hypotension

Potentially Fatal:

Arrhythmias
Agranulocytosis
Transient ischemic attack
Stroke
Neuroleptic malignant syndrome (NMS)
Agranulocytosis
Aspiration pneumonia
Hyperglycemia associated with ketoacidosis or hyperosmolar coma
Anaphylaxis
Angioedema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Precautions

Take extra caution in patients with the following medical conditions:

Risk factors for blood dyscrasia
Pre-existing low white blood cells
History of drug-induced leucopenia/neutropenia
Pre-existing abnormal lipid profile
Risk factors for aspiration pneumonia
Alzheimer’s disease
Heart failure
History of myocardial infarction or ischemia
Conduction abnormalities
Cerebrovascular disease
Predisposing conditions to hypotension
Dehydration
Hypovolemia
Conditions that increase risk of torsade de pointes or sudden death
Bradycardia
Hypokalemia
Hypomagnesemia
History of seizures or conditions that may lower seizure threshold
Alzheimer’s dementia
Head trauma
Brain damage
Alcoholism
Parkinson’s disease dementia or Lewy body dementia
Diabetes mellitus
Family history of diabetes
Obesity
Other disorders of glucose regulation
Patients undergoing strenuous exercise or exposed to extreme heat
Avoid abrupt withdrawal
Renal and moderate to severe hepatic impairment
Elderly with dementia-related psychosis
Pregnancy
Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Iloperidone may interact with the following medicines:

Ketoconazole
Clarithromycin
Fluoxetine
Paroxetine
Dextromethorphan
Midazolam
Antihypertensive agents
Anticholinergic agents

Potentially Fatal:

Quinidine
Procainamide
Amiodarone
Sotalol
Antiarrhythmics
Chlorpromazine
Thioridazine
Moxifloxacin
Gatifloxacin
Methadone
Pentamidine
Levomethadyl acetate

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Overdose & Brands

Symptoms:

Exaggeration of known pharmacologic effects
Drowsiness
Sedation
Tachycardia
Hypotension
Extrapyramidal symptoms
QTc interval prolongation

If an overdose is suspected, call your health care provider immediately.

Available brands:

Fanapt