HUMAN PAPILLOMAVIRUS 9-VALENT VACCINE

ILOPERIDONE

Iloperidone is an atypical antipsychotic having antagonistic action at dopamine D2 and serotonin (5-HT2), D3, and 1-adrenergic receptors. The combined antagonism is expected to alleviate psychosis’ unpleasant symptoms and reduce the occurrence of extrapyramidal side effects.

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose given by your physician is based on your health conditions, other medications or food supplements taken, and your reaction to the treatment. To diminish risks for adverse effects, do not increase your dosage, thus take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, take it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

Iloperidone is used in the following conditions:

  • Schizophrenia

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Iloperidone in people with the following conditions:

  • Congenital long QT syndrome
  • History of cardiac arrhythmias
  • Recent myocardial infarction
  • Uncompensated heart failure
  • Concomitant use with QTc-prolonging drugs

Iloperidone may have the following side effects:

  • Altered cardiac conduction and QTc interval prolongation
  • Leucopenia
  • Neutropenia
  • Central Nervous System depression
  • Dyslipidemia
  • Esophageal dysmotility and aspiration
  • Suicidal ideation
  • Orthostatic hypotension
  • Dizziness
  • Tachycardia
  • Syncope
  • Seizures
  • Extrapyramidal symptoms
  • Pseudoparkinsonism
  • Acute dystonic reactions
  • Akathisia
  • Tardive dyskinesia
  • Falls due to somnolence
  • Motor/sensory instability
  • Hyperprolactinemia
  • Weight gain
  • Impaired core body temperature regulation
  • Withdrawal symptoms
  • Priapism
  • Anemia
  • Palpitations
  • Blurred vision
  • Conjunctivitis
  • Nausea
  • Dry mouth
  • Diarrhea
  • Abdominal discomfort
  • Fatigue
  • Lethargy
  • Edema
  • Weight decreased
  • Increased appetite
  • Dehydration
  • Hypokalemia
  • Arthralgia
  • Myalgia
  • Musculoskeletal stiffness
  • Muscle spasms
  • Tremor
  • Paresthesia
  • Restlessness
  • Aggression
  • Delusion
  • Hostility
  • Libido decreased
  • Urinary incontinence
  • Ejaculation disorder
  • Erectile dysfunction
  • Amenorrhea
  • Gynecomastia
  • Galactorrhea
  • Nasal congestion
  • Nasopharyngitis
  • Upper respiratory tract infection
  • Dyspnea
  • Rash
  • Pruritus
  • Hypotension

Potentially Fatal: 

  • Arrhythmias
  • Agranulocytosis
  • Transient ischemic attack
  • Stroke
  • Neuroleptic malignant syndrome (NMS)
  • Agranulocytosis
  • Aspiration pneumonia
  • Hyperglycemia associated with ketoacidosis or hyperosmolar coma
  • Anaphylaxis
  • Angioedema

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more significant than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A severe allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Risk factors for blood dyscrasia
  • Pre-existing low white blood cells
  • History of drug-induced leucopenia/neutropenia
  • Pre-existing abnormal lipid profile
  • Risk factors for aspiration pneumonia
  • Alzheimer’s disease
  • Heart failure
  • History of myocardial infarction or ischemia
  • Conduction abnormalities
  • Cerebrovascular disease
  • Predisposing conditions to hypotension
  • Dehydration
  • Hypovolemia
  • Conditions that increase risk of torsade de pointes or sudden death
  • Bradycardia
  • Hypokalemia
  • Hypomagnesemia
  • History of seizures or conditions that may lower seizure threshold
  • Alzheimer’s dementia
  • Head trauma
  • Brain damage
  • Alcoholism
  • Parkinson’s disease dementia or Lewy body dementia
  • Diabetes mellitus
  • Family history of diabetes
  • Obesity
  • Other disorders of glucose regulation
  • Patients undergoing strenuous exercise or exposed to extreme heat
  • Avoid abrupt withdrawal
  • Renal and moderate to severe hepatic impairment
  • Elderly with dementia-related psychosis
  • Pregnancy
  • Lactation

Prior in taking this medicine, tell your physician or pharmacist if you have allergies or other hypersensitivity reactions with the drug. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.

Interactions

Iloperidone may interact with the following medicines:

  • Ketoconazole
  • Clarithromycin
  • Fluoxetine
  • Paroxetine
  • Dextromethorphan
  • Midazolam
  • Antihypertensive agents
  • Anticholinergic agents

Potentially Fatal:

  • Quinidine
  • Procainamide
  • Amiodarone
  • Sotalol
  • Antiarrhythmics
  • Chlorpromazine
  • Thioridazine
  • Moxifloxacin
  • Gatifloxacin
  • Methadone
  • Pentamidine
  • Levomethadyl acetate

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are possible, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms: 

  • Exaggeration of known pharmacologic effects
  • Drowsiness
  • Sedation
  • Tachycardia
  • Hypotension
  • Extrapyramidal symptoms
  • QTc interval prolongation

If an overdose is suspected, call your health care provider immediately.

Available brands:

  • Fanapt

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