Give with caution to pregnant and lactating women; elderly, debilitated and malnourished patients; and patients with hypersensitivity to other sulfonamide derivatives, autonomic neuropathy, G6PD deficiency, severe endocrine disorders and adrenal or pituitary insufficiency, mild to moderate renal or hepatic impairment.
Serum levels may be reduced by colesevelam. May increase hypoglycemic effect with MAOIs, chloramphenicol, fluoroquinolones (e.g. ciprofloxacin), probenecid, NSAIDs, ACE inhibitors, fluoxetine, disopyramide, clarithromycin, salicylates, sulfonamides, β-blockers. Increased serum levels with antifungal antibiotics (e.g. miconazole, fluconazole). May decrease hypoglycemic effect with nonthiazide (e.g. furosemide) and thiazide diuretics, corticosteroids, phenothiazines, thyroid agents, estrogens, OC, phenytoin, nicotinic acid, sympathomimetic agents, rifampicin, calcium channel blockers, isoniazid.
Potentially Fatal: May increase hepatotoxic effect of bosentan.