Giant axonal neuropathy (GAN) is a genetic disorder characterized by unusually large and defective axons, which are the specialized extensions of nerve cells that conduct nerve signals. In most instances, it is a serious, slowly progressing neurodegenerative condition marked by kinky hair, central nervous system dysfunction, and growing sensory and motor peripheral neuropathy.
Furthermore, giant axonal neuropathy is caused by an inherited autosomal recessive form, which implies that a kid with GAN has a copy of the defective gene in both parents. Usually, parents will exhibit no indicators of the condition. At the same time, most youngsters with GAN will develop symptoms before they turn five years old.