GEMEPROST

Gemeprost is a drug that belongs to a class of medicines known as alprostadil (prostaglandin E1) analogues. It softens and dilates the cervix and induces uterine contractions. It promotes cervical ripening during childbirth.

Gemeprost is used in cervical ripening before surgical termination of pregnancy or in fetal death in utero.

Gemeprost should not be given to women with the following conditions:

  • Uterine fragility related to uterine scarring (e.g. previous caesarean section or major uterine surgery)
  • Placenta praevia
  • Unexplained vaginal bleeding
  • Untreated pelvic infection

Gemeprost may give rise to the following side effects:

  • Uterine rupture
  • Spontaneous abortion
  • Vaginal bleeding
  • Mild uterine pain
    Headache
  • Dizziness
  • Weakness
    Palpitations
  • Severe hypotension
  • Chest pain
  • Tachycardia
  • Flushing
  • Nausea
  • Epigastric pain
  • Vomiting
  • Diarrhoea
  • Dyspnoea
  • Bronchoconstriction
  • Hypercontractility
  • Hypertonus
  • Back pain
  • Blurred vision
  • Chills
  • Mild fever
  • Serious cardiovascular accidents (e.g. MI, coronary artery spasm, severe hypotension, severe cardiogenic shock, vasospasm, stroke, ventricular standstill)
  • Uterine rupture during prolonged uterine hypotonia

Precautions

Extra precaution should be given in the following conditions:

  • COPD
  • Asthma
  • CV insufficiency
  • Elevated intraocular pressure
  • Cervicitis or vaginitis
  • Cervical stenosis
  • Multiparity
  • Twin pregnancy
  • Spontaneous abortion
  • Severe liver problem

 

Interactions

Gemeprost may interact with oxytocin and other labor inducers/accelerator drugs.

Symptoms of overdose include the following:

  • Sedation
  • Tremor
  • Convulsion
  • Dyspnoea
  • Abdominal pain and bloody diarrhea
  • Palpitations and bradycardia

Seek medical treatment immediately.

 

Available Brands:

  • Cergem
  • Cervagem
  • Cervidil

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