GANIRELIX

COMMON BRAND NAME(S): Antagon

GENERIC NAME(S): GANIRELIX ACETATE

 

Description: Ganirelix competitively blocks the gonadotropin-release hormone receptors on the pituitary gonadotroph and transduction pathway thus preventing ovulation until the follicles are of adequate size.

Pharmacokinetics:

Absorption: Rapidly absorbed after SC inj, with a bioavailability about 91%.

Metabolism: Metabolised by enzymatic hydrolysis.

Excretion: About 75% of a dose is excreted as metabolites in the faeces. Elimination half-life: About 13 hr.

Uses

This medication is generally used in combination with other hormones (FSH and hCG) as part of a treatment program for certain fertility problems in women.  It works by blocking the release of a certain hormone (luteinizing hormone) to delay ovulation and increase the chance of producing fertile eggs.

How to use ganirelix subcutaneous

Read the Patient Information Leaflet before starting this medication and each time you get a refill of this medication because new information may be available. You will be trained by a healthcare professional on how to properly use this medication. If any of the information is unclear, consult your healthcare professional.

Inject under the skin (subcutaneously) usually once daily, beginning several days after FSH injection is started, as directed by your doctor. Ganirelix and FSH injections are usually continued until the time of the hCG injection. You will be closely monitored by your doctor, who will determine the right time to discontinue ganirelix and FSH and to give the hCG injection. Follow your doctor’s exact instructions on when to start and stop this medication. Discuss your treatment with your doctor if you have any questions.

Wash hands with soap and water before using this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site daily to avoid discomfort or problem areas under the skin.

Inject the prescribed dose as directed by your doctor. Discard any unused portion of the medication immediately after the injection. Do not save it for future use.

Use this medication exactly as directed by your doctor in order to get the most benefit from it. Do not change the dose unless instructed by your doctor or use this medication for a longer period than prescribed.

Learn how to store and discard syringes, needles, and medical supplies safely. Consult your pharmacist for more information.

Side Effects

Notify your doctor or pharmacist promptly if any of these effects persist or worsen:

  • Redness or pain at the injection site
  • Headache
  • mild nausea/stomach pain
  • tiredness

Tell your doctor immediately if unusual vaginal bleeding occurs.

This medication may cause a condition known as Ovarian Hyperstimulation Syndrome (OHSS) which may occur during therapy and after treatment has been discontinued. Seek immediate medical attention if you develop the following side effects:

  • severe pain or swelling in the lower abdominal (pelvic) area
  • severe nausea/vomiting
  • sudden/rapid weight gain
  • change in the amount of urine.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other products containing gonadotropin releasing hormone (GnRH); or if you have any other allergies. Talk to your pharmacist for more details.

Multiple births may occur because of this treatment program. Consult your doctor for more details.

This medication must not be used during pregnancy because of possible harm to an unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately.

It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

 

Interactions

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose & Brands

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (e.g., blood hormone tests such as estradiol levels, vaginal ultrasound) should be performed to monitor your progress and check for side effects. Consult your doctor for more details.

It is important to keep all regular medical and laboratory appointments so your doctor can closely monitor your response to help reduce the risk of serious side effects and determine the duration of your therapy.

Missed Dose

It is important to use this medication at the correct schedule. If you miss a dose, contact your doctor or pharmacist immediately for instructions. Do not double the dose to catch up.

Storage

Store the medication away from light and moisture. Do not store in the bathroom. Do not freeze.

Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Brands

There are no brands containing this molecule.

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