Fotemustine is a strong antineoplastic drug because of its alkylating and carbamoylating property on the cell cycle. It is also a lipophilic drug allowing its transport along the blood brain barrier for the treatment of cerebral and visceral tumors.


Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully. 

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages. 

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day. 

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions. 

If you have any inquiries with regards to information, ask your physician or pharmacist. 

 Fotemustine is used in the following conditions:

  • Disseminated malignant melanoma.


This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use  Fotemustine in people with the following conditions:

  • Pregnancy
  • Lactation
  • Child

Fotemustine may have the following side effects:

  • Bone-marrow suppression and hematological toxicity (possibly delayed)
  • Gastrointestinal disturbances
  • Injection-site phlebitis
  • Fever
  • Pruritus
  • Neurological and biochemical disturbances
  • Transient rise in blood urea
  • Hepatic enzymes and bilirubin elevation


Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects.  

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing. 

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Elderly
  • Patients with renal or hepatic impairment
  • Recent chemotherapy
  • Monitor renal, hepatic and lung functions before and during treatment
  • Monitor blood counts weekly during treatment
  • Patients with reduced lung function


Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.



Fotemustine may interact with the following medicines:

  • Dacarbazine


Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins. 

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details. 

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking. 

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice. 

If you think you may have used Fotemustine more than the usual dose, please seek medical help immediately.


Available Brands:

  • Fotemustine-New Pioneer
  • Muphoran
  • Muphoran 200mg
  • Muphoran 200mg/4ml
  • Mustoforan
  • Mustophoran
  • Mustophoran 200 mg/4 ml

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