FOSFOMYCIN TROMETHAMINE

COMMON BRAND NAME(S): Monurol

GENERIC NAME(S): FOSFOMYCIN TROMETHAMINE

Description: Fosfomycin is an antibacterial that kills sensitive bacteria.

Pharmacokinetics:

Absorption: Rapidly absorbed from the GI tract (fosfomycin tromethamine). Time to peak plasma concentration: 4 hr. Bioavailability: Approx 30-40%.

Distribution: Widely distributed in body fluids including CSF and bile. Crosses the placenta and enters breast milk (small amounts). Volume of distribution: 0.3 L/kg.

Metabolism: Not metabolised by the liver.

Excretion: Via urine, as unchanged drug. Plasma half-life: Approx 2 hr.

This medication is an antibiotic used to treat bladder infections (e.g., acute cystitis or lower urinary tract infections) in women. It works by stopping the growth of bacteria.

 

Fosfomycin should not be used to treat infections outside the bladder (e.g., kidney infections such as pyelonephritis or perinephric abscesses).

 

This antibiotic treats only bacterial infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

 

How to use fosfomycin tromethamine:

Use 1 packet (3 grams) only. This is a single-dose treatment. Always mix this drug with water. Pour the contents of 1 packet (sachet) into at least a half glass (4 ounces or 120 milliliters) of cold water and stir. Do not use warm or hot water. Drink the mixture immediately. This drug may be taken with or without food.

 

Symptoms should improve within 2 to 3 days after taking this drug. If symptoms persist or worsen, contact your doctor promptly.

Pregnancy Risk: Category B (No proven risk in humans)

You should check with your doctor immediately if any of these side effects occur when taking fosfomycin:

Rare

  • Blood in the urine
  • burning while urinating
  • cough or hoarseness
  • difficult or painful urination
  • fever or chills
  • lower back or side pain
  • painful or difficult urination

Some of the side effects that can occur with fosfomycin may not need medical attention:

More common

  • Itching of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with a mild odor

Less common

  • Acid or sour stomach
  • back pain
  • belching
  • body aches or pain
  • congestion
  • dryness or soreness of the throat
  • heartburn
  • heavy bleeding
  • indigestion
  • lack or loss of strength
  • pain
  • painful menstruation
  • runny or stuffy nose
  • skin rash
  • sneezing
  • sore throat
  • stomach discomfort or upset
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes

weakness

Before taking fosfomycin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as the artificial sweetener saccharin), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

 

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

 

Do not use more than a single dose (1 packet or sachet) of this medication for each bladder infection. Using more packets will not make the drug work any better and may increase side effects.

 

If you develop symptoms of a kidney infection (such as pain in side/lower back area, fever, chills), contact your doctor immediately. You may need a different antibiotic to treat a kidney infection if one develops.

 

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

 

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

 

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

 

Interactions

 

Some products that may interact with this drug include: metoclopramide, probenecid.

 

Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin. Be sure to ask your doctor or pharmacist if you should use additional reliable birth control methods while using this antibiotic.

If overdose is suspected, contact a poison control center or emergency room immediately. Symptoms of overdose may include: hearing loss, metallic taste.

 

Notes

Do not share this medication with others.

 

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

 

Laboratory and/or medical tests (e.g., urine cultures) may be performed to monitor your progress. Consult your doctor for more details.

 

Missed Dose

Not applicable.

 

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

 

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Brands

 

Available Brands

Monurol [ Zambon ]

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