FLUCYTOSINE

COMMON BRAND NAME(S): Ancobon

GENERIC NAME(S): FLUCYTOSINE

 

Description: Flucytosine is an antifungal that  inhibits the growth of the fungi by being falsely incorporated into the fungal RNA or inhibiting thymidylate synthetase.

Pharmacokinetics:

Absorption: Rapidly absorbed and almost completely from the GI tract; bioavailability: 78-89%.

Distribution: Widely distributed in body tissues and fluids; readily penetrates the blood-brain barrier. Protein binding: 2-4%.

Metabolism: A small amount may be metabolised to fluorouracil.

Excretion: About 90% of a dose is excreted unchanged by glomerular filtration. Elimination half-life: 2.5-6 hr; increases with renal impairment.

Flucytosine is used to treat serious fungal infections in the body. It belongs to a class of drugs known as antifungal drugs. It is often used with other medications. It works by slowing the growth of certain types of fungus.

 

How to use flucytosine

Take this medication by mouth, usually 4 times a day (every 6 hours), or as directed by your doctor. To reduce stomach upset, do not swallow all of the capsules for one dose at the same time. It may be best to swallow the capsules for each dose over a 15-minute period until the full dose is taken.

 

The dosage is based on your medical condition, weight, and response to treatment.

 

This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

 

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a return of the infection.

 

Tell your doctor immediately if your condition persists or worsens.

This medication should be used with increased caution if you have kidney problems. Flucytosine may cause decreased kidney function and liver problems. In addition, this medication may decrease bone marrow function. This serious, possibly life-threatening side effect may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body’s ability to fight an infection, and cause bleeding problems. Your doctor will check the results of your kidney, liver, and blood tests and adjust your treatment to reduce your risk for these side effects. See also Side Effects section.

 

Pregnancy Risk: Category C (Risk cannot be ruled out)

You should check with your doctor immediately if any of these side effects occur when taking flucytosine:

More common

  • Skin rash, redness, or itching
  • sore throat and fever
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Less common

  • Confusion
  • hallucinations (seeing, hearing, or feeling things that are not there)
  • increased sensitivity of skin to sunlight

Some of the side effects that can occur with flucytosine may not need medical attention:

More common

  • Abdominal pain
  • diarrhea
  • loss of appetite
  • nausea or vomiting

Less common

  • Dizziness or lightheadedness
  • drowsiness

headache

Before taking flucytosine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

 

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, decreased bone marrow function, a low number of blood cells (red or white blood cells, platelets), radiation treatment, mineral imbalance (such as low level of potassium in the blood).

 

Wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

 

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

 

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

 

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to the side effects of this drug.

 

During pregnancy, this medication should be used only when clearly needed. This medication is not recommended for use during the first 3 months of pregnancy. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

 

It is not known whether this drug passes into breast milk. It may have undesirable effects on a nursing infant. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

 

Interactions

 

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

 

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor’s approval.

 

Some products that may interact with this drug include: cytarabine, other drugs that may affect the kidneys (including NSAIDs such as ibuprofen or naproxen), other drugs that decrease bone marrow function or lower your number of blood cells or weaken the immune system (such as cancer chemotherapy, trimethoprim/sulfamethoxazole).

 

This medication may interfere with certain laboratory tests (including serum creatinine), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

 

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

If overdose is suspected, contact a poison control center or emergency room immediately.

 

Notes

Do not share this medication with others.

 

Laboratory and/or medical tests (such as kidney and liver function, blood cell counts, blood mineral levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

 

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

 

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

 

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

 

Brands

 

There are no brands containing this molecule.

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