Flucloxacillin binds to certain penicillin-binding proteins (PBPs) within the bacterial cell membrane, inhibiting the third and last phases of cell wall production. It works against both staphylococci that produce penicillinase and those that don’t..

Use this medication precisely as recommended by your physician. Follow the prescription of your doctor carefully.

The medication dose your physician has given is based on your condition, other medications or food supplements you may take, and your reaction to treatment. To diminish your risks for adverse effects, don’t increase your dosage, take it regularly, or take it as instructed by your physician. Adverse events may still happen even at usual prescription dosages.

If your physician requests you to use this drug consistently, use it regularly to get the most benefits from it. To make you remember it better, take it at a fixed time every day.

Your doctor may need to modify your dosages to ease your symptoms or if you develop adverse reactions.

If you have any inquiries with regards to information, ask your physician or pharmacist.

Flucloxacillin is used in the following conditions:

  • Benzylpenicillin-resistant staphylococcal infections

This medicine may be recommended for different uses. Approach your physician or pharmacist for more information.

Do not use Flucloxacillin in people with the following conditions:

  • Higher sensitivity to flucloxacillin and other penicillin-like antibiotics
  • Person with a record of flucloxacillin-associated jaundice and hepatic impairment

Flucloxacillin may have the following side effects:

  • Urticaria
  • Pemphigoid reactions
  • Thrombocytopenia
  • Pruritus
  • Agranulocytosis
  • Neutropenia
  • Vasculitis
  • Haemolytic anemia
  • Maculopapular rashes
  • Phlebitis (IV)
  • Fever
  • Joint pains
  • Stevens-Johnson syndrome
  • Angioedema
  • Acute attacks of porphyria
  • Erythema nodosum
  • Nephropathy
  • Acute interstitial nephritis
  • Nausea
  • Hallucinations
  • Convulsions
  • Serum sickness-like reactions
  • Bronchospasm
  • Diarrhea
  • Electrolyte disturbances
  • Transient leucopenia
  • Vomiting
  • Candidiasis
  • Dyspnea
  • Erythema multiforme
  • Non-thrombocytopenic purpura
  • Toxic epidermal necrolysis

Potentially Fatal:

  • Anaphylaxis
  • Cholestatic jaundice
  • Hepatitis
  • Jarisch-Herxheimer reaction
  • Pseudomembranous colitis

Keep in mind that your physician has recommended this drug since he or she has known that the advantage to you is more noteworthy than the risk of adverse reactions. Many individuals utilizing this medicine don’t have serious side effects. 

A serious allergy to this medication is uncommon. In any case, seek emergency medical help if you see any manifestations of a serious allergic response, including a rash, tingling or swelling particularly of the face or tongue or throat, dizziness or difficulty in breathing.

This is not a complete list of side effects. If you see other effects not recorded above, contact your physician or pharmacist.

Take extra caution in patients with the following medical conditions:

  • Pregnancy
  • Patient w/ spirochete infections
  • Lactation
  • Hepatic or renal impairment
  • Newborn infants 
  • History of hypersensitivity to β-lactam antibiotics 

Prior to taking this medicine, tell your physician or pharmacist if you are allergic to it, or if you have some other hypersensitivities. This drug may contain inert ingredients which can cause unfavorable side effects or different issues. Talk with your pharmacist for more information.


Flucloxacillin may interact with the following medicines:

  • Tetracycline
  • Chloramphenicol
  • Estrogen-containing OC
  • Probenecid 
  • Oral anticoagulants
  • Estrogen-containing OC
  • Methotrexate toxicity

Inform your physician about the drugs you take including over-the-counter medications, prescribed drugs, supplements and vitamins.

This is not a complete list of drug interactions. Approach your physician or pharmacist for more details.

The effects of certain medications can change if you consume different medications or herbal products simultaneously. This can build your risk for side effects or may cause your drugs not to work effectively. These interactions are conceivable, yet don’t generally happen. Your physician or pharmacist can prevent or oversee interactions by changing how you utilize your prescriptions or by close checking.

While utilizing this drug, don’t start, stop, or change the dose of other medicines you are using without your physician’s advice.

Symptoms of overdose may include the following: 

  • Defective platelet function
  • Hemolytic anemia
  • Encephalopathy
  • Diarrhea
  • Vomiting
  • Neutropenia
  • Nausea
  • Prolongation of bleeding time
  • Convulsions
  • Electrolyte disturbances

Seek medical help immediately.

Available Brands:

  • Stafloxin
  • Drugmaker’s Flucloxacillin
  • Fluclox
  • Coxafen

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