FISH ODOR SYNDROME (Trimethylaminuria)

• Trimethylamine build up causes people with the condition to have their urine, breath and sweat smelling like a fish, with changing intensity over time. This pungent smell may cause problems in daily life, disturbing a person’s career, relationship or social life.
• Causes of the condition are as follows:
  • Gene mutation
  • Too much of certain proteins in diet
  • Increase in bacteria that produces trimethylamine in the digestive tract
  • Liver or kidney disease (few cases)
  • Prematurity
  • Beginning menstruation

DIAGNOSIS

• Physician may do/request:
  • History & Physical Exam
  • Urinalysis
    • For trimethylamine to trimethylamine oxide ratio
  • Blood test

RECOMMENDED MEDICATIONS

• Cure unknown
  • Symptomatic management and counseling may help
• Possible ways to decrease smell
  • Avoiding foods such as red meat, beans, egg yolks
  • Antibiotics (as prescribed by doctor)
  • Using slightly acidic detergent (pH between 5.5-6.5)