COMMON BRAND NAME(S): Uloric
GENERIC NAME(S): FEBUXOSTAT
Description: Febuxostat inhibits xanthine oxidase, and works by blocking an enzyme in the body (xanthine oxidase), which lowers levels of uric acid in the blood and prevent gout flare-ups.
Absorption: Rapidly and well absorbed (≥49%). High-fat meal may decrease peak plasma concentration. Time to peak plasma concentration: 1-1.5 hr.
Distribution: Plasma protein binding: Approx 99%.
Metabolism: Extensively metabolised via conjugation by the uridine diphosphate glucuronosyltransferase (UDPGT) enzyme system and via oxidation via the CYP450 isoenzyme system.
Excretion: Via urine (approx 49% as metabolites and 3% as unchanged drug); faeces (approx 45% as metabolites and 12% as unchanged drug). Mean terminal half-life: Approx 5-8 hr.