Recombinant factor VIIa is a form of activated factor VII that is created through recombinant DNA technology and is also known as a glycoprotein that depends on vitamin K for its actions. It leads to the formation of a blood clot by activation of the extrinsic pathway of coagulation.

Recombinant factor VIIa is used in the following medical conditions:

  • Haemophilia
  • Factor VII deficiency
  • Glanzmann’sthrombasthenia

Recombinant factor VIIa should not be given in patients with allergy to hamster, bovine or mouse proteins.

Recombinant factor VIIa may have the following side effects:

  • Nausea
  • Vomiting
  • Skin reactions
  • Fever
  • Headache
  • Changes in Blood pressure
  • Anaphylaxis


Take extra caution in patients with the following conditions:

  • Conditions associated with circulating tissue factor (e.g. advanced atherosclerosis, crush injury or septicaemia)
  • Risk of precipitating thrombosis
  • Risk of disseminated intravascular coagulation
  • Pregnancy and lactation



Recombinant factor VIIa may interact with activated or non-activated prothrombin complex concentrates.

If you think you may have overdosed, seek medical treatment immediately.


Available Brand:

  • Novoseven

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